Sunitinib malate
Tocris Bioscience, part of Bio-Techne | Catalog # 3768
Potent VEGFR, PDGFRβ and KIT inhibitor
Key Product Details
Description
Potent VEGFR, PDGFRβ and KIT inhibitor
Alternative Names
SU 11248
Product Description
Sunitinib malate is a potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor (Ki values are 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT respectively). Also inhibits cellular receptor phosphorylation of FLT3, RET and CSF-1R. Exhibits antiangiogenic and antitumor activity in multiple xenograft models.Licensing Information
Sold for research purposes under agreement from Pfizer Inc.Product Specifications
Molecular Weight
532.56
Formula
C22H27FN4O2.C4H6O5
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidine)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-2-hydroxybutanedioate salt
CAS Number
341031-54-7
PubChem ID
6456015
InChI Key
LBWFXVZLPYTWQI-IPOVEDGCSA-N
SMILES
O=C(NCCN(CC)CC)C1=C(C)NC(/C=C2\C(NC3=C2C=C(F)C=C3)=O)=C1C.OC(C[C@H](O)C(O)=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 13.31 | 25 |
Preparing Stock Solutions
for Sunitinib malate
The following data is based on the product molecular weight 532.56
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 7.51 mL | 37.55 mL | 75.11 mL |
| 1.25 mM | 1.50 mL | 7.51 mL | 15.02 mL |
| 2.5 mM | 0.75 mL | 3.76 mL | 7.51 mL |
| 12.5 mM | 0.15 mL | 0.75 mL | 1.50 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Roskoski Sunitinib: a VEGF and PDGF receptor protein kinase and angiogenesis inhibitor. Biochem.Biophys.Res.Comm. 2007 PMID: 17367763
- O'Farrell SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo. Blood 2003 PMID: 12531805
- Faivre Molecular basis for suni. efficacy and future clinical development Nat.Rev.Drug Discov. 2007 PMID: 17690708
- Mendel In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin.Cancer Res. 2003 PMID: 12538485
Product Specific Notices for Sunitinib malate
For research use only
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