DDR1-IN-1 dihydrochloride

Name: DDR1-IN-1 dihydrochloride
Brand: Tocris Bioscience
SKU: 5077
Rating: 5 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 5077

Citations (4)

(1)

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Key Product Details

Description:	Selective DDR1 inhibitor
Chemical Name:	N-[3-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)oxy]-4-methylphenyl]-4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)benzamide dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	625.51

View Full Technical Details for DDR1-IN-1 dihydrochloride

Biological Activity for DDR1-IN-1 dihydrochloride

DDR1-IN-1 dihydrochloride is a selective discoidin domain receptor 1 (DDR1) tyrosine kinase inhibitor (IC₅₀ values are 105 and 413 nM for DDR1 and DDR2 respectively). Inhibits integrin-induced DDR1 autophosphorylation in an osteosarcoma cell line.

Compound Libraries for DDR1-IN-1 dihydrochloride

DDR1-IN-1 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of DDR1-IN-1 is reviewed on the chemical probes website.

Technical Data for DDR1-IN-1 dihydrochloride

M. Wt	625.51
Formula	C₃₀H₃₁F₃N₄O₃.2HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1780303-76-5
PubChem ID	90489006
InChi Key	PBUOJKYQZINPKD-UHFFFAOYSA-N
Smiles	CC1=C(OC4=CC(CC(N5)=O)=C5C=C4)C=C(NC(C2=CC=C(CN3CCN(CC)CC3)C(C(F)(F)F)=C2)=O)C=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for DDR1-IN-1 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	62.55	100
	DMSO	31.28	50

Preparing Stock Solutions for DDR1-IN-1 dihydrochloride

The following data is based on the product molecular weight 625.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.60 mL	7.99 mL	15.99 mL
5 mM	0.32 mL	1.60 mL	3.20 mL
10 mM	0.16 mL	0.80 mL	1.60 mL
50 mM	0.03 mL	0.16 mL	0.32 mL

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References for DDR1-IN-1 dihydrochloride

References are publications that support the biological activity of the product.

Canning Structural Mechanisms Determining Inhibition of the Collagen Receptor DDR1 by Selective and Multi-Targeted Type II Kinase Inhibitors. J.Mol.Biol. 2014 PMID: 24768818
Kim Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor. ACS.Chem.Biol. 2013 PMID: 23899692

Citations for DDR1-IN-1 dihydrochloride (4)

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Citations are publications that use Bio-Techne products. Selected citations for DDR1-IN-1 dihydrochloride include:

Romayor et al. (2020) Silencing of sinusoidal DDR1 reduces murine liver metastasis by colon carcinoma. Sci Rep. 10:18398
PMID: 33110221
Vehlow et al. (2019) Interaction of Discoidin Domain Receptor 1 with a 14-3-3-Beclin-1-Akt1 Complex Modulates Glioblastoma Therapy Sensitivity. Cell Rep. 26:3672
PMID: 30917320
Mogami (2018) Collagen Type 1 accelerates healing of ruptured fetal membranes. Sci Rep. 8(1):696
PMID: 29330408
Malaguarnera et al. (2015) Novel cross talk between IGF-IR and DDR1 regulates IGF-IR trafficking, signaling and biological responses. BMC Complement Altern Med. 6:16084
PMID: 25840417

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Customer Reviews for DDR1-IN-1 dihydrochloride (1)

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Collagen type 1 activated collagen receptor discoidin domain receptor

Name: Anonymous

Species: Mouse

Assay Type: In Vitro

Cell Line/Tissue: 3D Culture Matrix

10 μg/ml treat 24h and 48h

PMID: 29330408

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