DDR1-IN-1 dihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 5077
Selective DDR1 inhibitor
Product Description
DDR1-IN-1 dihydrochloride is a selective discoidin domain receptor 1 (DDR1) tyrosine kinase inhibitor (IC50 values are 105 and 413 nM for DDR1 and DDR2 respectively). Inhibits integrin-induced DDR1 autophosphorylation in an osteosarcoma cell line.External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of DDR1-IN-1 is reviewed on the chemical probes website.Product Specifications
Molecular Weight
625.51
Formula
C30H31F3N4O3.2HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
N-[3-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)oxy]-4-methylphenyl]-4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)benzamide dihydrochloride
CAS Number
1780303-76-5
PubChem ID
90489006
InChI Key
PBUOJKYQZINPKD-UHFFFAOYSA-N
SMILES
CC1=C(OC4=CC(CC(N5)=O)=C5C=C4)C=C(NC(C2=CC=C(CN3CCN(CC)CC3)C(C(F)(F)F)=C2)=O)C=C1.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 62.55 | 100 | |
| DMSO | 31.28 | 50 |
Preparing Stock Solutions
for DDR1-IN-1 dihydrochloride
The following data is based on the product molecular weight 625.51
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.60 mL | 7.99 mL | 15.99 mL |
| 5 mM | 0.32 mL | 1.60 mL | 3.20 mL |
| 10 mM | 0.16 mL | 0.80 mL | 1.60 mL |
| 50 mM | 0.03 mL | 0.16 mL | 0.32 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Canning Structural Mechanisms Determining Inhibition of the Collagen Receptor DDR1 by Selective and Multi-Targeted Type II Kinase Inhibitors. J.Mol.Biol. 2014 PMID: 24768818
- Kim Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor. ACS.Chem.Biol. 2013 PMID: 23899692
Product Specific Notices for DDR1-IN-1 dihydrochloride
For research use only
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