UNC 2881
Tocris Bioscience, part of Bio-Techne | Catalog # 6537
Potent Mer kinase inhibitor
Product Description
UNC 2881 is a potent Mer kinase inhibitor. Displays >55-fold selectivity for Mer kinase over other TAM receptor tyrosine kinase family members (IC50 values are 4.3 nM, 0.25 μM and 0.36 μM for Mer, Tyro3 and Alk, respectively). Inhibits Mer phosphorylation in vitro. Also inhibits platelet aggregation in response to Type I collagen.Product Specifications
Molecular Weight
463.58
Formula
C25H33N7O2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
2-(Butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-[[4-(1H-imidazol-1-yl)phenyl]methyl]-5-pyrimidinecarboxamide
CAS Number
1493764-08-1
PubChem ID
71721525
InChI Key
NPVXOWLPOFYACO-UHFFFAOYSA-N
SMILES
CCCCNC1=NC=C(C(N[C@H]2CC[C@@H](CC2)O)=N1)C(NCC3=CC=C(N4C=CN=C4)C=C3)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 23.18 | 50 |
Preparing Stock Solutions
for UNC 2881
The following data is based on the product molecular weight 463.58
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.31 mL | 21.57 mL | 43.14 mL |
| 2.5 mM | 0.86 mL | 4.31 mL | 8.63 mL |
| 5 mM | 0.43 mL | 2.16 mL | 4.31 mL |
| 25 mM | 0.09 mL | 0.43 mL | 0.86 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Zhang Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis. J.Med.Chem. 2013 PMID: 24219778
Product Specific Notices for UNC 2881
For research use only
Loading...
Loading...