Additional RTK Inhibitors Small Molecules and Peptides

c-Fms inhibitor; suppresses osteolysis and osteoclast accumulation

VEGFR inhibitor. Also inhibits KIT, RET, MET and FLT3

Potent and selective PDGFR family inhibitor

Selective DDR1 inhibitor

Potent CSF-1R inhibitor

Potent and selective FGFR inhibitor

Potent VEGFR, PDGFRβ and KIT inhibitor

PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor

Potent RET inhibitor

PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor

Potent c-SRC kinase inhibitor; also inhibits DDR2, BTK and Syk

Selective cFMS kinase inhibitor; orally bioavailable

Potent and selective DDR1 inhibitor; orally bioavailable

Potent Mer kinase inhibitor

Potent Tie2 inhibitor

Zap70 inhibitor; inhibits interaction with ITAMs

Potent and selective dual inhibitor of the IGF-1 receptor and insulin receptor

Potent and selective RET inhibitor

PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor

Potent and selective discoidin domain receptor 1/2 inhibitor

Potent inhibitor of VEGFR, PDGFR and FGFR

Induces growth and proliferation of pancreatic islet cells, murine totipotent stem cells, GABAergic neurons and hippocampal neurons

Dual Mer/Axl inhibitor