Ki 20227

Name: Ki 20227
Brand: Tocris Bioscience
SKU: 4481

Tocris Bioscience, part of Bio-Techne | Catalog # 4481

Citations (13)

COA / SDS

c-Fms inhibitor; suppresses osteolysis and osteoclast accumulation

Key Product Details

Description:	c-Fms inhibitor; suppresses osteolysis and osteoclast accumulation
Chemical Name:	N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]-2-methoxyphenyl]-N'-[1-(2-thiazolyl)ethyl]urea
Purity:	≥97% (HPLC)
Molecular Weight:	480.54

View Full Technical Details for Ki 20227

Technical Data
Citations

Biological Activity for Ki 20227

Ki 20227 is an inhibitor of c-Fms tyrosine kinase (M-CSFR, CSF1R) (IC₅₀ values are 2, 12, 217 and 451 nM for c-Fms, VEGFR-2, PDGFRβ and c-Kit respectively). Does not inhibit Flt3, EGFR or c-Src. Suppresses osteoclast differentiation and osteolysis in a rat bone metastasis model.

Compound Libraries for Ki 20227

Ki 20227 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for Ki 20227

M. Wt	480.54
Formula	C₂₄H₂₄N₄O₅S
Storage	Store at +4°C
Purity	≥97% (HPLC)
CAS Number	623142-96-1
PubChem ID	9869779
InChi Key	SHPFDGWALWEPGS-UHFFFAOYSA-N
Smiles	O=C(NC(C)C3=NC=CS3)NC(C(OC)=C2)=CC=C2OC1=C4C(C=C(OC)C(OC)=C4)=NC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ki 20227

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	48.05	100

Preparing Stock Solutions for Ki 20227

The following data is based on the product molecular weight 480.54.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.08 mL	10.40 mL	20.81 mL
5 mM	0.42 mL	2.08 mL	4.16 mL
10 mM	0.21 mL	1.04 mL	2.08 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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References for Ki 20227

References are publications that support the biological activity of the product.

Ohno The orally-active and selective c-Fms tyrosine kinase inhibitor Ki20227 inhibits disease progression in a collagen-induced arthritis mouse model. Eur.J.Immunol. 2007 PMID: 18085662
Ohno A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model. Mol.Cancer Ther. 2006 PMID: 17121910
Kubota M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis. J.Exp.Med. 2009 PMID: 19398755