XL 184

Tocris Bioscience, part of Bio-Techne | Catalog # 5422

COA / SDS

Potent VEGFR inhibitor; also inhibits other RTKs

Key Product Details

Description:	Potent VEGFR inhibitor; also inhibits other RTKs
Alternative Names:	Cabozantinib,BMS 907351
Chemical Name:	N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl]-N-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	501.51

View Full Technical Details for XL 184

Technical Data
Citations

Biological Activity for XL 184

XL 184 is a potent VEGFR inhibitor (IC₅₀ = 0.035 nM); also inhibits c-Met, KIT, RET, FLT4, AXL, FLT3, FLT1 and Tie2 (IC₅₀ values are 1.3, 4.6, 5.2, 6, 7, 11.3, 12 and 14.3 nM, respectively). Induces intratumoral hypoxia and apoptosis. Reduces tumor invasion and metastasis in vivo. Antiangiogenic.

Compound Libraries for XL 184

XL 184 is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for XL 184

M. Wt	501.51
Formula	C₂₈H₂₄FN₃O₅
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	849217-68-1
PubChem ID	25102847
InChi Key	ONIQOQHATWINJY-UHFFFAOYSA-N
Smiles	COC1=CC2=C(C=C1OC)N=CC=C2OC3=CC=C(NC(C4(CC4)C(NC5=CC=C(F)C=C5)=O)=O)C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for XL 184

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	50.15	100

Preparing Stock Solutions for XL 184

The following data is based on the product molecular weight 501.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.99 mL	9.97 mL	19.94 mL
5 mM	0.40 mL	1.99 mL	3.99 mL
10 mM	0.20 mL	1.00 mL	1.99 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

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References for XL 184

References are publications that support the biological activity of the product.

Yakes Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth. Mol.Cancer Ther. 2011 PMID: 21926191
You VEGF and c-Met blockade amplify angiogenesis inhibition in pancreatic islet cancer. Cancer Res. 2012 PMID: 21613405