KG 5
Tocris Bioscience, part of Bio-Techne | Catalog # 5260
PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor
Key Product Details
Description
PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor
Product Description
KG 5 is a PDGFRβ and B-Raf allosteric inhibitor. Also inhibits c-Raf, FLT3 and KIT. Disrupts blood vessel formation in zebrafish embryos and inhibits angiogenesis in a mouse angiogenesis model. Inhibits growth of renal and pancreatic tumors in mice. Also arrests cells in prometaphase. Orally available.Product Specifications
Molecular Weight
459.45
Formula
C20H16F3N7OS
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-(Methylthio)-6-[4-[5-[[3-(trifluoromethyl)phenyl]amino]-1H-1,2,4-triazol-3-yl]phenoxy]-4-pyrimidinamine
CAS Number
877874-85-6
PubChem ID
53328059
InChI Key
CMYHZFCJPORPHY-UHFFFAOYSA-N
SMILES
NC1=NC(SC)=NC(OC(C=C4)=CC=C4C3=NN=C(N3)NC2=CC(C(F)(F)F)=CC=C2)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 45.94 | 100 | |
| Ethanol | 45.94 | 100 |
Preparing Stock Solutions
for KG 5
The following data is based on the product molecular weight 459.45
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.18 mL | 10.88 mL | 21.77 mL |
| 5 mM | 0.44 mL | 2.18 mL | 4.35 mL |
| 10 mM | 0.22 mL | 1.09 mL | 2.18 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Mielgo A MEK-independent role for CRAF in mitosis and tumor progression. Nat.Med. 2011 PMID: 22081024
- Murphy Disruption of angiogenesis and tumor growth with an orally active drug that stabilizes the inactive state of PDGFRbeta/B-RAF. Proc.Natl.Acad.Sci.U.S.A. 2010 PMID: 20154271
Product Specific Notices for KG 5
For research use only
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