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Raf Kinase Inhibitors Products

Raf-1 is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. The activated Raf-1 can phosphorylate and activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the Serine/Threonine specific protein kinases ERK1 and ERK2. Downstream of Raf-1, activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation, and cell migration.

12 results for "Raf Kinase Inhibitors" in Products

Raf Kinase Inhibitors Products

Raf-1 is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. The activated Raf-1 can phosphorylate and activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the Serine/Threonine specific protein kinases ERK1 and ERK2. Downstream of Raf-1, activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation, and cell migration.

12 results for "Raf Kinase Inhibitors" in Products

Potent B-Raf inhibitor

Potent BRAF and CRAF inhibitor

Potent B-Raf inhibitor

Potent, selective c-Raf inhibitor

Potent and selective B-Raf, CDK16 and NEK9 inhibitor; anticancer; also targets human proteins in the SARS-CoV-2 interactome

Potent Raf kinase inhibitor

PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor

Potent, selective c-Raf1 kinase inhibitor

Potent pan-Raf kinase inhibitor

Potent BRAF PROTAC®

Negative control for SJF 0628 (Cat. No. 7463)

Potent Raf-1 inhibitor; also inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and cKIT

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