SJF 0661

Name: SJF 0661
Brand: Tocris Bioscience
SKU: 7464

Tocris Bioscience a Bio-Techne Brand

Catalog # 7464

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Key Product Details

Description:	Negative control for SJF 0628 (Cat. No. 7463)
Chemical Name:	(2S,4S)-1-((S)-2-(2-(4-(4-(3-(2,6-Difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperazin-1-yl)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	1010.19

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Biological Activity for SJF 0661

SJF 0661 is the negative control for SJF 0628 (Cat. No. 7463). Binds BRAF without inducing degradation.

Technical Data for SJF 0661

M. Wt	1010.19
Formula	C₅₁H₅₇F₂N₉O₇S₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2413035-43-3
PubChem ID	146502225
InChi Key	MBCAVOCJJAQHHT-NYNRYUPBSA-N
Smiles	CCCS(=O)(NC1=CC=C(C(C(C2=CNC3=NC=C(C4=CC=C(N5CCN(CC5)CC(N[C@@H](C(C)(C)C)C(N6C[C@H](C[C@H]6C(NCC7=CC=C(C8=C(N=CS8)C)C=C7)=O)O)=O)=O)C=C4)C=C23)=O)=C1F)F)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SJF 0661

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	101.02	100

Preparing Stock Solutions for SJF 0661

The following data is based on the product molecular weight 1010.19.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	0.99 mL	4.95 mL	9.90 mL
5 mM	0.20 mL	0.99 mL	1.98 mL
10 mM	0.10 mL	0.49 mL	0.99 mL
50 mM	0.02 mL	0.10 mL	0.20 mL

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References for SJF 0661

References are publications that support the biological activity of the product.

Alabi Mutant-selective degradation by BRAF-targeting PROTACs. Nat.Commun. 2021 PMID: 33568647

Citations for SJF 0661

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SJF 0661

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Biological Activity for SJF 0661

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Preparing Stock Solutions for SJF 0661

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References for SJF 0661

Citations for SJF 0661

Product Documents for SJF 0661

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