AC 710

Tocris Bioscience a Bio-Techne Brand

Catalog # 5013

Citations (1)

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Key Product Details

Description:	Potent and selective PDGFR family inhibitor
Chemical Name:	N-[4-[[[[5-(1,1-Dimethethylethyl)-3-isoxazolyl]amino]carbonyl]amino]phenyl]-5-[(1-ethyl-2,2,6,6-tetramethyl-4-piperidinyl)oxy]-2-pyridinecarboxamide
Purity:	≥99% (HPLC)
Molecular Weight:	562.7

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Biological Activity for AC 710

AC 710 is a potent PDGFR family inhibitor (IC₅₀ values are 1.2, 2, 7.7 and 10.5 nM for KIT, FLT3, PDGFRβ and CSF1R respectively; K_d = 1.3 nM for PDGFRα). Exhibits >30-fold selectivity over a panel of other kinases and exhibits no activity against cytochrome P450. Causes tumor regression of leukemia cell xenografts in mice. Also reduces joint swelling and inflammation in a mouse model of collagen-induced arthritis. Orally active.

Compound Libraries for AC 710

AC 710 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for AC 710

M. Wt	562.7
Formula	C₃₁H₄₂N₆O₄
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	1351522-04-7
PubChem ID	54760053
InChi Key	JVCWPUFNLFSKFS-UHFFFAOYSA-N
Smiles	CC(C2)(C)N(CC)C(C)(C)CC2OC1=CC=C(C(NC3=CC=C(NC(NC4=NOC(C(C)(C)C)=C4)=O)C=C3)=O)N=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AC 710

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	11.25	20

Preparing Stock Solutions for AC 710

The following data is based on the product molecular weight 562.7.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	8.89 mL	44.43 mL	88.86 mL
1 mM	1.78 mL	8.89 mL	17.77 mL
2 mM	0.89 mL	4.44 mL	8.89 mL
10 mM	0.18 mL	0.89 mL	1.78 mL

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References for AC 710

References are publications that support the biological activity of the product.

Liu Discovery of AC710, a globally selective inhibitor of platelet-derived growth factor receptor-family kinases. ACS Med.Chem.Lett. 2012 PMID: 24900421

Citations for AC 710 (1)

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Citations are publications that use Bio-Techne products. Selected citations for AC 710 include:

Srinivasan (2018) Substrate stiffness modulates the multipotency of human neural crest derived ectomesenchymalstem cells via CD44 mediated PDGFR signaling. Biomaterials. 167:153
PMID: 29571051

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Product Documents for AC 710

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.