Linifanib

Name: Linifanib
Brand: Tocris Bioscience
SKU: 7743

Tocris Bioscience, part of Bio-Techne | Catalog # 7743

Citations (2)

COA / SDS

Potent inhibitor of PDGFRβ, KDR, FLT3 and CSF-1R

Key Product Details

Description:	Potent inhibitor of PDGFRβ, KDR, FLT3 and CSF-1R
Chemical Name:	N-[4-(3-Amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea
Purity:	≥98% (HPLC)
Molecular Weight:	375.4

View Full Technical Details for Linifanib

Technical Data
Citations

Biological Activity for Linifanib

Linifanib is a potent receptor tyrosine kinase (RTK) inhibitor. It inhibits PDGFRβ, KDR, FLT3, CSF-1R (IC₅₀ values are 2, 4, 4 and 7 nM, respectively). Linifanib inhibits angiogenesis in vascularized micro-organs and potently inhibits VEGF-stimulated endothelial cell proliferation (IC₅₀= 0.2 nM). Linifanib also promotes the generation and reprogramming of iPSCs from somatic cells.

Technical Data for Linifanib

M. Wt	375.4
Formula	C₂₁H₁₈FN₅O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	796967-16-3
PubChem ID	11485656
InChi Key	MPVGZUGXCQEXTM-UHFFFAOYSA-N
Smiles	O=C(NC=1C=CC(=CC1)C=2C=CC=C3NN=C(N)C32)NC4=CC(=CC=C4F)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Linifanib

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	7.51	20
	DMSO	37.54	100

Preparing Stock Solutions for Linifanib

The following data is based on the product molecular weight 375.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.66 mL	13.32 mL	26.64 mL
5 mM	0.53 mL	2.66 mL	5.33 mL
10 mM	0.27 mL	1.33 mL	2.66 mL
50 mM	0.05 mL	0.27 mL	0.53 mL

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References for Linifanib

References are publications that support the biological activity of the product.

Guan Chemical reprogramming of human somatic cells to pluripotent stem cells. Nature 2022 PMID: 35418683
Jahid Structure-based design of CDC42 effector interaction inhibitors for the treatment of cancer. Cell Rep. 2022 PMID: 35385746
Albert Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitor. Mol.Cancer Ther. 2006 PMID: 16648571