Linifanib

Tocris Bioscience, part of Bio-Techne | Catalog # 7743

Potent inhibitor of PDGFRβ, KDR, FLT3 and CSF-1R
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Key Product Details

Description

Potent inhibitor of PDGFRβ, KDR, FLT3 and CSF-1R

View all PDGF Receptor Inhibitors »

Product Description

Linifanib is a potent receptor tyrosine kinase (RTK) inhibitor. It inhibits PDGFRβ, KDR, FLT3, CSF-1R (IC50 values are 2, 4, 4 and 7 nM, respectively). Linifanib inhibits angiogenesis in vascularized micro-organs and potently inhibits VEGF-stimulated endothelial cell proliferation (IC50 = 0.2 nM). Linifanib also promotes the generation and reprogramming of iPSCs from somatic cells.

Product Specifications

Molecular Weight

375.40

Formula

C21H18FN5O

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-[4-(3-Amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea

CAS Number

796967-16-3

PubChem ID

11485656

InChI Key

MPVGZUGXCQEXTM-UHFFFAOYSA-N

SMILES

O=C(NC=1C=CC(=CC1)C=2C=CC=C3NN=C(N)C32)NC4=CC(=CC=C4F)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.54 100
Ethanol 7.51 20

Preparing Stock Solutions for Linifanib

The following data is based on the product molecular weight 375.40

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.66 mL 13.32 mL 26.64 mL
5 mM 0.53 mL 2.66 mL 5.33 mL
10 mM 0.27 mL 1.33 mL 2.66 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Linifanib

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Linifanib

For research use only

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