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Simple Plex Assays for Inflammatory Biomarker Research

See how Simple Plex assays on the Ella platform are used to profile inflammatory biomarkers.

The systemic cytokine and chemokine cascades set off by acute inflammatory responses require a fast, sensitive and standardized immunoassay format to profile accurately. Automated Simple Plex™ assays on Ella™ get you that critical immune reactivity information and inflammation status data by simply adding your sample and buffers to a cartridge and pressing Start.

Accelerate Inflammatory Cytokine Detection With Ella

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Measure Key Cytokines Fast

Whether you're a researcher tackling cytokine release syndrome, sepsis, the pertinent COVID-19 pandemic, or other acute respiratory failure research, reliably monitoring the inflammatory response is the crux of your ability to make informed decisions. And Ella delivers the results you need, fast.

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Ultra-Sensitive Biomarker Detection

With a four-log range of detection, Simple Plex assays have the sensitivity to pick up even very low picogram-per-milliliter levels of endogenous analyte.

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Industry Leader in Quality

Simple Plex assays are developed by the industry leader in immunoassays, R&D Systems, so you know a high level of quality and validation is behind Ella, and will provide you with the analytical power and assay sensitivity needed to support your inflammation research.

Ella Promises Better Clinical Care For Acute Respiratory Failure and Sepsis


"Timely results from Ella have the potential to direct treatment for acute diseases where administration needs to take place in a matter of hours."

- Michael Matthay, M.D., Ph.D., Professor of Medicine, University of California San Francisco

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Biomarkers for Inflammation Assays

These analytes are key for monitoring immune reactivity and have been implicated in acute inflammatory responses to pathologies such as cytokine release syndrome, sepsis, COVID-19, and acute respiratory distress syndrome.

Simple Plex Inflammatory Markers

Simplifying and Expediting Inflammatory Biomarker Research With Ella


"Ella is the closest I’ve seen to my goal of one day having a Star Trek-like tricorder. I can take just 25 μL of serum, add it to a cartridge, and in 90 minutes have immune profiling data."

- E. Scott Halstead, M.D., Ph.D., Associate Professor, Department of Pediatrics, Penn State University College of Medicine

Inflammation Resources

Ella Characterizes Cytokine Release Syndrome Biomarkers In CAR T‑Cell Therapy

Correlating biomarkers with clinical evidence is essential for the safe delivery of CAR T-cell therapies, and, therefore, for the full realization of their therapeutic potential. To do this, fast and accurate evaluation and monitoring of the immune response is necessary. Download this poster to see how researchers at Moffit Cancer Center use Ella to quantitate relevant biomarker levels in the serum of CAR T donors compared with healthy controls.

Poster thumbnail - Characterizing CAR T Cell Therapy Biomarkers Through Multianalyte Analysis
App Note thumbnail - Detecting and Analyzing Cytokines the Simple Plex Way

Fast and Reproducible Quantitation of Cytokines With Ella

Manual immunoassay workflows are error-prone and struggle with reproducibility and variability of results—results that take hours of time to produce and analyze. Not with Ella. Download this application note for a glimpse of peer-reviewed work from researchers around the globe using Ella to reliably and quickly measure cytokines.

Additional Literature | Simple Plex in Inflammation Research

Learn how Ella is already advancing inflammatory biomarker research.

  1. Leligdowicz, et al. (2017) Validation of two multiplex platforms to quantify circulating markers of inflammation and endothelial injury in severe infection PLoS ONE 14:e0175130. PMID: 28419100.
  2. Fischer et al. (2019) Development of an IL-6 point-of-care assay: Utility for real-time monitoring and management of cytokine release syndrome and sepsis Bioanalysis 11:1777. PMID: 31547696