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Simple Plex™ Assays for COVID-19 Research

First, see how Simple Plex assays on the EllaTM platform are used for COVID-19 research. Next, meet Ella and request pricing. Finally, choose the Simple Plex Assay that best meets your needs.

Table of Contents

Real-Time Biological Phenotyping

When researching an acute SARS-CoV-2 infection and the resulting and deadly COVID-19 disease, speed and data quality are key. Ella enables cytokine and pro-inflammatory biomarker immunoassays in a multianalyte, automated and standardized format. Get the most reliable immunoassay results in real time with Ella.

  • After loading the cartridge, data is available in just 75 minutes, getting you to critical decision points faster
  • Factory calibrated cartridges and built-in standard curves minimize inter-lot variability allowing you to get the same measurement anywhere
  • 80% reduction in manual steps eliminates operator error and inconsistent results



How Ella Is Helping During the COVID-19 Pandemic

Ella is at the forefront of the fight against COVID-19. The Human Immune Monitoring Center at Mount Sinai is leveraging the high-quality data and real-time results of Ella to understand if an immunologic response during COVID-19 is turning deadly. This insight is helping them determine if novel immuno-modulating therapies have the potential to mediate response to the virus.

Watch this virtual meeting organized by the NIH and FDA, to learn more about the role of cytokines in COVID-19 and how researchers at Mount Sinai established a rapid and quantitative cytokine test on Ella to obtain actionable immune monitoring data during the management of COVID-19 patients.

COVID-19 research virtual meeting using automated ELISA system Ella

Watch Mount Sinai’s Miriam Merad, M.D., Ph.D. discuss the progress they’ve made using Ella for real-time immune profiling of the hyperinflammatory response during COVID-19 in this webinar.

Webinar on how Mount Sinai uses automated immunoassay platform Ella for Covid-19 research

Researchers at the Ichan School of Medicine at Mount Sinai published in Nature Medicine using The Cytokine Storm Panel on Ella! Read their work, entitled, “An Inflammatory cytokine signature predicts COVID-19 severity and survival”.

Nature Medicine Logo



Simple Plex Assays for COVID-19 Research: From Your Peers

Dr. Bermejo Martin discusses host response to COVID infection using Simple Plex assays on Ella

Profiling Host Responses In COVID-19 Infections: Accelerating Biomarker Research With Ella

"A major advantage of Ella is that it’s very easy to use with virtually no maintenance, and it’s really fast. Simply dilute your sample and you’re ready to go—without the need for manual preparations that can take time and add user variability."

- Dr. Jesús F Bermejo-Martín, Principal Investigator, Institute of Biomedical Research of Salamanca (IBSAL)/Hospital Universitario Río Hortega de Valladolid

Michael Matthay uses Ella to identify biomarkers important in acute respiratory failure and sepsis

Ella Promises Better Clinical Care For Acute Respiratory Failure And Sepsis

"Timely results from Ella have the potential to direct treatment for acute diseases where administration needs to take place in a matter of hours."

- Michael Matthay, M.D., Ph.D., Professor of Medicine, University of California San Francisco

Anthony Tanoto Tan, Ph.D uses Simple Plex assays to profile T cell responses in SARS-CoV-2 infection

Characterizing T-Cell Immune Responses Against Sars-Cov-2 With Ella

"Ella is a simple and fast immunoassay platform that would be ideal for implementation in higher biosafety facilities, like BSL-3, to study the acute phase of SARS-CoV-2 infection."

- Anthony Tanoto Tan, Ph.D., Senior Research Fellow, Duke-NUS Medical School, Singapore

COVID-19 Research Publications Using Ella

  1. Le Bert et al. (2021) Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 Infection J. Exp. Med. 218:e20202617. PMID: 33646265.

  2. Mandel et al. (2020) Cytokine prediction of mortality in COVID19 patients Cytokine 134:155190. PMID: 32673995.

  3. Bordoni et al. (2020) An inflammatory profile correlates with decreased frequency of cytotoxic cells in COVID-19 Clinical Infectious Diseases 21:2272. PMID: 32407466.

  4. Agrati et al. (2020) Expansion of myeloid-derived suppressor cells in patients with severe coronavirus disease (COVID-19) Cell Death & Differentiation 27:3196. PMID: 32514047.



Simple Plex COVID-19 Cytokine Storm Panel

Measure key inflammation markers that are indicative of pathologic inflammatory response with a high-quality multianalyte assay. The 16x4 COVID-19 Cytokine Storm Panel is perfect for batching small numbers of samples and getting results fast. 


COVID-19 Cytokine Storm Panel Markers

Ella cartridge 16x4

Simple Plex™ Cytokine Screening Panel

The 32x8 Multiplex Cytokine Screening Panel gives you deep insight into an immunological response across a spectrum of critical markers. Get up to 256 results in just 90 minutes. Learn more about the multiplex cartridge.

Cytokine Screening Panel Markers

Ella cartridge 32x8

In response to the global COVID-19 pandemic, the COVID-19 Cytokine Storm Panel and Multiplex Cytokine Screening Panel are available off the shelf  Off-the-shelf cartridges ship within 48 hours in the continental US.

DISCLAIMER:  The Ella™ automated immunoassay platform is currently offered For Research Use Only;  Not for Use in Diagnostic Procedures.

Bio-Techne's Tools For Coronavirus Research

As a leading company in the life sciences research sector, Bio-Techne develops products and resources to support coronavirus research, including reagents and platforms for SARS-CoV-2 detection, cytokine monitoring, and drug discovery. These tools help the scientific community better understand the mechanisms of infection and develop effective treatments. Learn more about Bio-Techne's portfolio or products for Coronavirus Research.

Covid-19 Product Cells

Simple Plex Applications

sars cov-2 virus

COVID-19 Research

Quantify cytokine and pro-inflammatory responses to SARS-CoV-2 infection in 90 minutes using an automated, multianalyte format.

joint inflammation

Inflammation Research

Simple Plex assays enable rapid and reproducible quantification of inflammatory responses such as cytokine release syndrome and sepsis. 

immune cells attack cancer cell

Cancer Biomarker Research

Simple Plex assays for cancer research have the sensitivity to profile low abundance cancer biomarkers.

neuronal network

Neuroscience Research

Measure key neuroscience biomarkers such as neurofilament light (NF-L) and neurofilament heavy (NF-H) in CSF, plasma, and serum.

Cell and gene therapy

Cell Therapy Research and Development

The Simple Plex HEK 293 HCP 3G assay on the Ella platform offers broad detection coverage of this host cell protein (HCP).

protein bioprocessing workflow

Bioprocess Testing

Iterate your workflow faster with Simple Plex CHO HCP 3G-1 assays for process-related impurity testing.

preclinical scientist pipetting in the lab

Preclinical Research

With a four-log range of detection, Simple Plex assays have the sensitivity to pick up even very low picogram-per-milliliter levels of endogenous mouse or rat analytes.

AAV2 virus for simple plex

Viral Titer Assays

Get highly reproducible adeno-associated virus and lentivirus titer data with no manual steps in just 90 minutes.

Other Simple Plex Products

Automated ELISA platform assay options including singleplex, multianalyte and multiplex assay cartridges



  16x1 32x1 16x2 16x3 16x4 32x2 72x1 72x2 32x3 32x4 32x5 32x6 32x7 32x8
Samples 16 32 16 16 16 32 72 72 32 32 32 32 32 32
Plex 1 1 2 3 4 2 1 2 3 4 5 6 7 8
Replicates 3 3 3 3 3 3 3 2 3 3 2 2 2 2
Reportable Results 16 32 32 48 64 64 72 144 96 128 160 192 224 256