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TNF-alpha: Simple Plex

TNF-alpha (Tumor necrosis factor alpha) plays a central role in inflammation, immune system development, apoptosis, and lipid metabolism. TNF-alpha was first identified as a cytotoxic factor produced by macrophages capable of killing mouse tumor cells. It is the prototypic ligand and along with Lymphotoxin-alpha, were identified as the first members of the TNF superfamily. Active TNF-alpha and other members of the TNF superfamily exist as a homotrimer with high structural homology. Receptor binding occurs at the interface of two TNF-alpha monomers. And receptor activation occurs when all three monomer interfaces are engaged with a receptor. For TNF-alpha, receptor binding and activation occurs through TNF R1 or TNF RII, and subsequently leads to activation of NF-kB or MAPK signaling pathways. Another pathway that TNF-alpha can activate utilizes the death domain of TNF RI to induce apoptosis. TNF-alpha promotes the inflammatory response largely through NF-kB signaling, and inhibition of TNF-alpha has proven successful in treating many autoimmune disorders. TNF-alpha is also present on the cell surface as membrane-bound TNF-alpha can induce the lysis of neighboring tumor cells and virus infected cells. TNF-alpha protein is translated as a type II transmembrane protein containing an N-terminal transmembrane domain. The soluble cytokine is released from its cell-anchoring TM domain by proteolytic processing by metalloproteases.

12 results for "TNF-alpha Simple Plex" in Products

TNF-alpha: Simple Plex

TNF-alpha (Tumor necrosis factor alpha) plays a central role in inflammation, immune system development, apoptosis, and lipid metabolism. TNF-alpha was first identified as a cytotoxic factor produced by macrophages capable of killing mouse tumor cells. It is the prototypic ligand and along with Lymphotoxin-alpha, were identified as the first members of the TNF superfamily. Active TNF-alpha and other members of the TNF superfamily exist as a homotrimer with high structural homology. Receptor binding occurs at the interface of two TNF-alpha monomers. And receptor activation occurs when all three monomer interfaces are engaged with a receptor. For TNF-alpha, receptor binding and activation occurs through TNF R1 or TNF RII, and subsequently leads to activation of NF-kB or MAPK signaling pathways. Another pathway that TNF-alpha can activate utilizes the death domain of TNF RI to induce apoptosis. TNF-alpha promotes the inflammatory response largely through NF-kB signaling, and inhibition of TNF-alpha has proven successful in treating many autoimmune disorders. TNF-alpha is also present on the cell surface as membrane-bound TNF-alpha can induce the lysis of neighboring tumor cells and virus infected cells. TNF-alpha protein is translated as a type II transmembrane protein containing an N-terminal transmembrane domain. The soluble cytokine is released from its cell-anchoring TM domain by proteolytic processing by metalloproteases.

12 results for "TNF-alpha Simple Plex" in Products

Simple Plex 16x4 Panel including IFN-y 3rd gen, IL-6 2nd gen, IL-8, and TNF-a 2nd gen

Simple Plex Cartridge Kit for quantitation of TNF-alpha. Includes wash buffer and sample diluent SD13. For use with the Ella automated immunoassay system.

Simple Plex Cartridge Kit for quantitation of TNF-alpha. Includes wash buffer and sample diluent. For use with the Ella automated immunoassay system.

Catalog #: 894977

Control for use with Human TNF-alpha Simple Plex Cartridge Kit

Simple Plex 16x4 Panel including Granzyme B, IFN-y 3rd Gen, IL-8/CXCL8, and TNF-a 2nd Gen

Simple Plex 16x4 Panel including IFN-y, IL-2, IL-6, and TNF-a

Simple Plex 16x6 Panel including IL-10, IL-2, IFN-y 3rd gen, TNF-a 2nd gen, IL-8/CXCL8, and IL-6 2nd gen

Simple Plex 16x6 Panel including IL-1b, IL-12 p70, IL-10, IL-2, IFNg 3rd gen, TNF-a 2nd gen, IL-4 2nd gen, and IL-6 2nd gen

Catalog #: 898308

Control for use with Mouse TNF-alpha Simple Plex Cartridge Kit

Simple Plex 16x4 including GRANB, IFNg 3rd gen, IL-2, and TNF-a 2nd gen

Simple Plex 16x4 Panel including IFN-y 3rd gen, IL-6 2nd gen, IL-8, and TNF-a 2nd gen

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