Skip to main content

Simple Plex™ Assays for Preclinical Research

First, see how Simple Plex assays on the EllaTM platform are used for preclinical research. Next, meet Ella and request pricing. Finally, choose the Simple Plex Assay that best meets your needs.

Table of Contents

More Efficient Immunoassays For Preclinical Research

Preclinical development is a critical period of the drug development process and Simple Plex can help you get more data from precious samples, reducing the need for expensive animal models.

Compared to traditional plate-based approaches Simple Plex assays reduce sample volume requirements by up to 90%, making sure that samples from your models are available for all the characterization you need.

With a highly automated and standardized workflow Simple Plex assays also decrease the operator time required to execute an immunoassay by 80%, which ensures your scientists are free to take on higher values activities, and your therapeutic gets to the next stage faster.

preclinical scientist pipetting in the lab

Low Volume High-Quality Immunoassay Results

  • Simple Plex mouse and rat assays require at most 25µl of sample and provide up to 12 data points from each sample
  • With a four-log range of detection, Simple Plex assays have the sensitivity to pick up even very low picogram-per-milliliter levels of endogenous analyte
  • Ella ensures the standardization of your immunoassay, as everything is pre-packaged, pre-optimized, and pre-loaded



Simple Plex Mouse Assays For Preclinical Research

Simple Plex mouse assays are available in multianalyte (32x4, 16x4) and single plex (72x1) formats.

Simple Plex Mouse Markers
Angiopoietin-2 IL-1-beta MCP-1/CCL2
CCL4 IL-17 Neurofilament Light (NF-L)
CD25/IL-2 Ra IL-1ra/IL-1F3 Osteopontin (OPN)
CXCL1/KC IL-2 SDF-1 alpha/CXCL12
CXCL2/MIP-2 IL-5 TGF-beta 1
Cystatin C IL-6 TNF-alpha
IFN-gamma IP-10/CXCL10



Simple Plex Rat Assays For Preclinical Research

Simple Plex rat assays are available in multianalyte (32x4, 16x4) and single plex (72x1) formats.

Simple Plex Rat Markers
Angiopoietin-2 Lipocalin 2 Osteopontin (OPN)
CD25/IL-2 Ra MCP-1/CCL2 TGF-beta 1
Cystatin C NF-L TIM-1



The Industry Leader In Quality

Simple Plex assays are developed by the industry leader in immunoassays, R&D Systems. So you know a high level of quality and validation is behind Ella, and will provide you with the analytical power and assay sensitivity needed to support your inflammation research.

  • Brought to you by the makers of Quantikine® ELISA kits, Simple Plex assays continue a legacy of quality immunoassays
  • Our vertically integrated supply chain ensures you get the same results years into the future
logo for RnD Systems, a Bio-Techne brand

Browse the full Simple Plex assay menu, see how Ella works or talk to one of our Immunoassay specialists about inflammatory biomarker assay solutions for your lab. Add cartridge formats

Simple Plex Applications

sars cov-2 virus

COVID-19 Research

Quantify cytokine and pro-inflammatory responses to SARS-CoV-2 infection in 90 minutes using an automated, multianalyte format.

joint inflammation

Inflammation Research

Simple Plex assays enable rapid and reproducible quantification of inflammatory responses such as cytokine release syndrome and sepsis. 

immune cells attack cancer cell

Cancer Biomarker Research

Simple Plex assays for cancer research have the sensitivity to profile low abundance cancer biomarkers.

neuronal network

Neuroscience Research

Measure key neuroscience biomarkers such as neurofilament light (NF-L) and neurofilament heavy (NF-H) in CSF, plasma, and serum.

Cell and gene therapy

Cell Therapy Research and Development

The Simple Plex HEK 293 HCP 3G assay on the Ella platform offers broad detection coverage of this host cell protein (HCP).

protein bioprocessing workflow

Bioprocess Testing

Iterate your workflow faster with Simple Plex CHO HCP 3G-1 assays for process-related impurity testing.

preclinical scientist pipetting in the lab

Preclinical Research

With a four-log range of detection, Simple Plex assays have the sensitivity to pick up even very low picogram-per-milliliter levels of endogenous mouse or rat analytes.

AAV2 virus for simple plex

Viral Titer Assays

Get highly reproducible adeno-associated virus and lentivirus titer data with no manual steps in just 90 minutes.

Simple Plex Assay Denominations

Automated ELISA platform assay options including singleplex, multianalyte and multiplex assay cartridges



  16x1 32x1 16x2 16x3 16x4 32x2 72x1 72x2 32x3 32x4 32x5 32x6 32x7 32x8
Samples 16 32 16 16 16 32 72 72 32 32 32 32 32 32
Plex 1 1 2 3 4 2 1 2 3 4 5 6 7 8
Replicates 3 3 3 3 3 3 3 2 3 3 2 2 2 2
Reportable Results 16 32 32 48 64 64 72 144 96 128 160 192 224 256