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PD-L1/B7-H1 Products
PD-L1, also known as B7-H1 and CD274, is an approximately 65 kDa transmembrane glycoprotein in the B7 family of immune regulatory molecules. PD-L1 is expressed on inflammatory-activated immune cells including macrophages, T cells, and B cells, keratinocytes, enothelial and intestinal epithelial cells, as well as a variety of carcinomas and melanoma. PD-L1 protein binds to T cell B7-1/CD80 and PD-1. It suppresses T cell activation and proliferation and induces the apoptosis of activated T cells. It plays a role in the development of immune tolerance by promoting T cell anergy and enhancing regulatory T cell development. PD-L1 favors the development of anti-inflammatory IL-10 and IL-22 producing dendritic cells and inhibits the development of Th17 cells. In cancer, PD-L1 provides resistance to T cell mediated lysis, enhances EMT, and enhances the tumorigenic function of Th22 cells. Many tumors overexpress PD-L1 protein making the PD-1:PD-L1 interaction central to several successful cancer immunotherapy approaches.
117 results for "PD-L1/B7-H1" in Products
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PD-L1/B7-H1 Products
PD-L1, also known as B7-H1 and CD274, is an approximately 65 kDa transmembrane glycoprotein in the B7 family of immune regulatory molecules. PD-L1 is expressed on inflammatory-activated immune cells including macrophages, T cells, and B cells, keratinocytes, enothelial and intestinal epithelial cells, as well as a variety of carcinomas and melanoma. PD-L1 protein binds to T cell B7-1/CD80 and PD-1. It suppresses T cell activation and proliferation and induces the apoptosis of activated T cells. It plays a role in the development of immune tolerance by promoting T cell anergy and enhancing regulatory T cell development. PD-L1 favors the development of anti-inflammatory IL-10 and IL-22 producing dendritic cells and inhibits the development of Th17 cells. In cancer, PD-L1 provides resistance to T cell mediated lysis, enhances EMT, and enhances the tumorigenic function of Th22 cells. Many tumors overexpress PD-L1 protein making the PD-1:PD-L1 interaction central to several successful cancer immunotherapy approaches.
117 results for "PD-L1/B7-H1" in Products
WB, Flow, IHC, CyTOF-ready
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | CyTOF-ready, Flow Cytometry, Immunohistochemistry, Western Blot |
Bind
| Source : | HEK293 |
| Accession # : | Q9NZQ7 |
| Applications : | Binding Activity |
Catalog #:
SPCK-PANEL
Design and order Simple Plex cartridges tailor made to meet your needs with customizable Simple Plex Assay panels for the Ella platform.
Luminex Discovery Assays provide the most flexible assays on the market. These panels are completely customizable using our large menu of human, mouse, and rat analytes, making them the perfect tool for biomarker discovery and screening.
Build your own Luminex Assay with our Luminex Assay Customization Tool.
Catalog #:
FCSTM24
Luminex High Performance Assays go through rigorous development, validation, and quality control testing to ensure you are getting the best performance out of your multiplex assay. Panels are customizable so you can order a selection of the analytes or the entire panel.
ELISA
Luminex High Performance Assays go through rigorous development, validation, and quality control testing to ensure you are getting the best performance out of your multiplex assay. Panels are customizable so you can order a selection of the analytes or the entire panel.
| Applications : | ELISA |
Catalog #:
FCSTM18B
ELISA
Luminex High Performance Assays go through rigorous development, validation, and quality control testing to ensure you are getting the best performance out of your multiplex assay. Panels are customizable so you can order a selection of the analytes or the entire panel.
| Applications : | ELISA |
Product in process of being discontinued and replaced by a new, improved panel
BA
| Source : | NS0 |
| Accession # : | Q9NZQ7 |
| Applications : | Bioactivity |
Catalog #:
LKTM013
Earn double rewards for reviews
ELISA
Luminex High Performance Assays go through rigorous development, validation, and quality control testing to ensure you are getting the best performance out of your multiplex assay. Panels are customizable so you can order a selection of the analytes or the entire panel.
| Applications : | ELISA |
Product in process of being discontinued and replaced by a new, improved panel
Catalog #:
SPCKB-PS-003468
Simple Plex Cartridge Kit for quantitation of B7-H1. Includes wash buffer and sample diluent. For use with the Ella automated immunoassay system.
ELISA
| Sensitivity : | 4.52 pg/mL |
| Assay Range : | 25 - 1,600 pg/mL (Cell Culture Supernates, Cell Lysates, Serum, EDTA Plasma, Heparin Plasma, Urine) |
| Applications : | ELISA |
BA
| Source : | NS0 |
| Accession # : | Q9EP73 |
| Applications : | Bioactivity |
Catalog #:
MAB1562
WB, Flow, CyTOF-ready, Neut
Recombinant Monoclonal Antibody.
| Clonality : | Monoclonal |
| Host : | Rabbit IgG Clone #2340D |
| Applications : | Block/Neutralize, CyTOF-ready, Flow Cytometry, Western Blot |
ELISA
| Assay Range : | 156.25 - 10,000 pg/mL |
| Applications : | ELISA |
WB
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Western Blot |
WB, Simple Western, ELISA, IHC
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | ELISA, Immunohistochemistry, Simple Western, Western Blot |
Catalog #:
MAB10348
Flow, CyTOF-ready
Recombinant Monoclonal Antibody For Research Use Only
| Clonality : | Monoclonal |
| Host : | Human IgG1 Clone #Hu124 |
| Applications : | CyTOF-ready, Flow Cytometry |
