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PD-L1/B7-H1 Products

PD-L1, also known as B7-H1 and CD274, is an approximately 65 kDa transmembrane glycoprotein in the B7 family of immune regulatory molecules. PD-L1 is expressed on inflammatory-activated immune cells including macrophages, T cells, and B cells, keratinocytes, endothelial and intestinal epithelial cells, as well as a variety of carcinomas and melanoma. PD-L1 protein binds to T cell B7-1/CD80 and PD-1.

It suppresses T cell activation and proliferation and induces the apoptosis of activated T cells. It plays a role in the development of immune tolerance by promoting T cell anergy and enhancing regulatory T cell development. PD-L1 favors the development of anti-inflammatory IL-10 and IL-22 producing dendritic cells and inhibits the development of Th17 cells. In cancer, PD-L1 provides resistance to T cell mediated lysis, enhances EMT, and enhances the tumorigenic function of Th22 cells. Many tumors overexpress PD-L1 protein making the PD-1:PD-L1 interaction central to several successful cancer immunotherapy approaches.

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575 results for "PD-L1/B7-H1" in Products

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PD-L1/B7-H1 Products

PD-L1, also known as B7-H1 and CD274, is an approximately 65 kDa transmembrane glycoprotein in the B7 family of immune regulatory molecules. PD-L1 is expressed on inflammatory-activated immune cells including macrophages, T cells, and B cells, keratinocytes, endothelial and intestinal epithelial cells, as well as a variety of carcinomas and melanoma. PD-L1 protein binds to T cell B7-1/CD80 and PD-1.

It suppresses T cell activation and proliferation and induces the apoptosis of activated T cells. It plays a role in the development of immune tolerance by promoting T cell anergy and enhancing regulatory T cell development. PD-L1 favors the development of anti-inflammatory IL-10 and IL-22 producing dendritic cells and inhibits the development of Th17 cells. In cancer, PD-L1 provides resistance to T cell mediated lysis, enhances EMT, and enhances the tumorigenic function of Th22 cells. Many tumors overexpress PD-L1 protein making the PD-1:PD-L1 interaction central to several successful cancer immunotherapy approaches.

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575 results for "PD-L1/B7-H1" in Products

Analyzed by SEC-MALS

WB, Flow, IHC, CyTOF-ready, Dual ISH-IHC
IHC, WB, ICC/IF, ELISA, Flow, Dual ISH-IHC, IP, KD
IHC, WB

Recombinant Monoclonal Antibody

Recombinant Monoclonal Antibody

Recombinant Monoclonal Antibody

Recombinant Monoclonal Antibody

Recombinant Monoclonal Antibody

Recombinant Monoclonal Antibody

WB, Simple Western, ELISA, IHC

Simple Plex Human PD-L1/B7-H1 2nd Gen assay kit for use on Ella instrument. Contains cartridge, sample diluent SD13 and SD10, and wash buffer.

Recombinant Monoclonal Antibody.

Flow, IHC, CyTOF-ready, Dual ISH-IHC

Simple Plex Cartridge Kit for quantitation of PD-L1/B7-H1. Includes wash buffer and sample diluent SD13. For use with the Ella automated immunoassay system.

WB, Flow, CyTOF-ready, Neut

Recombinant Monoclonal Antibody.

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