PD-L1/B7-H1: Antibodies
PD-L1, also known as B7-H1 and CD274, is an approximately 65 kDa transmembrane glycoprotein in the B7 family of immune regulatory molecules. PD-L1 is expressed on inflammatory-activated immune cells including macrophages, T cells, and B cells, keratinocytes, enothelial and intestinal epithelial cells, as well as a variety of carcinomas and melanoma. PD-L1 protein binds to T cell B7-1/CD80 and PD-1. It suppresses T cell activation and proliferation and induces the apoptosis of activated T cells. It plays a role in the development of immune tolerance by promoting T cell anergy and enhancing regulatory T cell development. PD-L1 favors the development of anti-inflammatory IL-10 and IL-22 producing dendritic cells and inhibits the development of Th17 cells. In cancer, PD-L1 provides resistance to T cell mediated lysis, enhances EMT, and enhances the tumorigenic function of Th22 cells. Many tumors overexpress PD-L1 protein making the PD-1:PD-L1 interaction central to several successful cancer immunotherapy approaches.
73 results for "PD-L1/B7-H1 Primary Antibodies" in Products
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PD-L1/B7-H1: Antibodies
PD-L1, also known as B7-H1 and CD274, is an approximately 65 kDa transmembrane glycoprotein in the B7 family of immune regulatory molecules. PD-L1 is expressed on inflammatory-activated immune cells including macrophages, T cells, and B cells, keratinocytes, enothelial and intestinal epithelial cells, as well as a variety of carcinomas and melanoma. PD-L1 protein binds to T cell B7-1/CD80 and PD-1. It suppresses T cell activation and proliferation and induces the apoptosis of activated T cells. It plays a role in the development of immune tolerance by promoting T cell anergy and enhancing regulatory T cell development. PD-L1 favors the development of anti-inflammatory IL-10 and IL-22 producing dendritic cells and inhibits the development of Th17 cells. In cancer, PD-L1 provides resistance to T cell mediated lysis, enhances EMT, and enhances the tumorigenic function of Th22 cells. Many tumors overexpress PD-L1 protein making the PD-1:PD-L1 interaction central to several successful cancer immunotherapy approaches.
73 results for "PD-L1/B7-H1 Primary Antibodies" in Products
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #130021 |
Applications : | CyTOF-ready, Flow Cytometry, Immunohistochemistry |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | CyTOF-ready, Flow Cytometry, Immunohistochemistry, Western Blot |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | ELISA, Immunohistochemistry, Simple Western, Western Blot |
Recombinant Monoclonal Antibody.
Clonality : | Monoclonal |
Host : | Rabbit IgG Clone #2340D |
Applications : | Block/Neutralize, CyTOF-ready, Flow Cytometry, Western Blot |
Recombinant Monoclonal Antibody.
Clonality : | Monoclonal |
Host : | Rabbit IgG Clone #2096C |
Applications : | Flow Cytometry, Immunohistochemistry, Western Blot |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | Western Blot |
Recombinant Monoclonal Antibody For Research Use Only
Clonality : | Monoclonal |
Host : | Human IgG1 Clone #Hu125 |
Applications : | CyTOF-ready, Flow Cytometry |
Clonality : | Monoclonal |
Host : | Rat IgG2a Clone #929903 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #130021 |
Applications : | Flow Cytometry |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | Flow Cytometry, Western Blot |
Recombinant Monoclonal Antibody.
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #130021R |
Applications : | CyTOF-ready, ELISA, Flow Cytometry |
Recombinant Monoclonal Antibody For Research Use Only
Clonality : | Monoclonal |
Host : | Human IgG1 Clone #Hu124 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Rat IgG2a Clone #179711 |
Applications : | Western Blot |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #130021 |
Applications : | Flow Cytometry |
Recombinant Monoclonal Antibody.
Clonality : | Monoclonal |
Host : | Rabbit IgG Clone #2341A |
Applications : | Block/Neutralize, CyTOF-ready, Flow Cytometry, Western Blot |
Recombinant Monoclonal Antibody For Research Use Only
Clonality : | Monoclonal |
Host : | Human IgG1 Clone #Hu124 |
Applications : | Flow Cytometry |
Recombinant Monoclonal Antibody.
Clonality : | Monoclonal |
Host : | Rabbit IgG Clone #2096C |
Applications : | Flow Cytometry |
Recombinant Monoclonal Antibody For Research Use Only
Clonality : | Monoclonal |
Host : | Human IgG1 Clone #Hu125 |
Applications : | Flow Cytometry |
Recombinant Monoclonal Antibody For Research Use Only
Clonality : | Monoclonal |
Host : | Human IgG1 Clone #Hu124 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Rat IgG2a Clone #929903 |
Applications : | CyTOF-ready, Flow Cytometry |
Recombinant Monoclonal Antibody.
Clonality : | Monoclonal |
Host : | Rabbit IgG Clone #2096C |
Applications : | Flow Cytometry |
Recombinant Monoclonal Antibody.
Clonality : | Monoclonal |
Host : | Rabbit IgG Clone #2096C |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Mouse IgG1 Clone #130021 |
Applications : | Flow Cytometry |
Recombinant Monoclonal Antibody.
Clonality : | Monoclonal |
Host : | Rabbit IgG Clone #2340D |
Applications : | Flow Cytometry |
Recombinant Monoclonal Antibody For Research Use Only
Clonality : | Monoclonal |
Host : | Human IgG1 Clone #Hu124 |
Applications : | CyTOF-ready, Flow Cytometry |