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PD-L1/B7-H1: Antibodies

PD-L1, also known as B7-H1 and CD274, is an approximately 65 kDa transmembrane glycoprotein in the B7 family of immune regulatory molecules. PD-L1 is expressed on inflammatory-activated immune cells including macrophages, T cells, and B cells, keratinocytes, enothelial and intestinal epithelial cells, as well as a variety of carcinomas and melanoma. PD-L1 protein binds to T cell B7-1/CD80 and PD-1. It suppresses T cell activation and proliferation and induces the apoptosis of activated T cells. It plays a role in the development of immune tolerance by promoting T cell anergy and enhancing regulatory T cell development. PD-L1 favors the development of anti-inflammatory IL-10 and IL-22 producing dendritic cells and inhibits the development of Th17 cells. In cancer, PD-L1 provides resistance to T cell mediated lysis, enhances EMT, and enhances the tumorigenic function of Th22 cells. Many tumors overexpress PD-L1 protein making the PD-1:PD-L1 interaction central to several successful cancer immunotherapy approaches.

73 results for "PD-L1/B7-H1 Primary Antibodies" in Products

PD-L1/B7-H1: Antibodies

PD-L1, also known as B7-H1 and CD274, is an approximately 65 kDa transmembrane glycoprotein in the B7 family of immune regulatory molecules. PD-L1 is expressed on inflammatory-activated immune cells including macrophages, T cells, and B cells, keratinocytes, enothelial and intestinal epithelial cells, as well as a variety of carcinomas and melanoma. PD-L1 protein binds to T cell B7-1/CD80 and PD-1. It suppresses T cell activation and proliferation and induces the apoptosis of activated T cells. It plays a role in the development of immune tolerance by promoting T cell anergy and enhancing regulatory T cell development. PD-L1 favors the development of anti-inflammatory IL-10 and IL-22 producing dendritic cells and inhibits the development of Th17 cells. In cancer, PD-L1 provides resistance to T cell mediated lysis, enhances EMT, and enhances the tumorigenic function of Th22 cells. Many tumors overexpress PD-L1 protein making the PD-1:PD-L1 interaction central to several successful cancer immunotherapy approaches.

73 results for "PD-L1/B7-H1 Primary Antibodies" in Products

Flow, IHC, CyTOF-ready
WB, Flow, IHC, CyTOF-ready
WB, Simple Western, ELISA, IHC
WB, Flow, CyTOF-ready, Neut

Recombinant Monoclonal Antibody.

Recombinant Monoclonal Antibody.

Flow, CyTOF-ready

Recombinant Monoclonal Antibody For Research Use Only

Catalog #: FAB9078S
Flow
Flow
Catalog #: BAF1019
WB, Flow
ELISA, Flow, CyTOF-ready

Recombinant Monoclonal Antibody.

Catalog #: FAB10348G
Flow

Recombinant Monoclonal Antibody For Research Use Only

Flow
WB, Flow, Block, CyTOF-ready

Recombinant Monoclonal Antibody.

Catalog #: FAB10348N
Flow

Recombinant Monoclonal Antibody For Research Use Only

Catalog #: FAB90781G
Flow

Recombinant Monoclonal Antibody.

Catalog #: FAB10355R
Flow

Recombinant Monoclonal Antibody For Research Use Only

Catalog #: FAB10348R
Flow

Recombinant Monoclonal Antibody For Research Use Only

Flow, CyTOF-ready
Catalog #: FAB90781R
Flow

Recombinant Monoclonal Antibody.

Catalog #: FAB90781N
Flow

Recombinant Monoclonal Antibody.

Catalog #: FAB1562G
Flow

Recombinant Monoclonal Antibody.

Flow, CyTOF-ready

Recombinant Monoclonal Antibody For Research Use Only

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