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18 results for "Methyltransferase Inhibitors" in Products

Methyltransferase Inhibitors Products

Protein Arginine methyltransferases, or PRMTs, are a family of enyzmes that catalyze the transfer of methyl groups from S-adenosylmethionine (SAM) to arginine residues on histones. PRMTs belong to the histone methyltransferase group of enzymes, which also includes lysine methyltransferases. They are also closely related in biological activity to the DNA methyltransferases and are ubiquitously expressed. Histone methylation of arginine residues occurs predominantly on histones H2A, H3 and H4, ...

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DNA methyltransferase inhibitor

Alternate Names: 2'-Deoxy-5-azacytidine,5-Aza-2'-deoxycytidine,NSC 127716
Chemical Name: 4-Amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one
Purity: ≥98% (HPLC)
DNA methyltransferase inhibitor

DNA methyltransferase inhibitor

Chemical Name: 4-Amino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one
Purity: ≥98% (HPLC)
DNA methyltransferase inhibitor

Non-nucleoside DNA methyltransferase inhibitor

Chemical Name: N-Phthalyl-L-tryptophan
Purity: ≥98% (HPLC)
Non-nucleoside DNA methyltransferase inhibitor

Selective ASH1L histone methyltransferase inhibitor

Chemical Name: N-[[3-[3-(Aminothioxomethyl)phenyl]-1-[1-[(trifluoromethyl)sulfonyl]-4-piperidinyl]-1H-indol-6-yl]methyl]-1-methyl-3-azetidinecarboxamide
Purity: ≥98% (HPLC)
Selective ASH1L histone methyltransferase inhibitor

Potent and selective PRMT 4 inhibitor

Chemical Name: N-Methyl-N-((2-(1-(2-(methylamino)ethyl)piperidin-4-yl)pyridin-4-yl)methyl)-3-phenoxybenzamide
Purity: ≥98% (HPLC)
Potent and selective PRMT 4 inhibitor

Potent and selective SETD7 inhibitor

Chemical Name: 8-Fluoro-1,2,3,4-tetrahydro-N-[(1R)-2-oxo-2-(1-pyrrolidinyl)-1-[[3-(trifluoromethyl)phenyl]methyl]ethyl]-6-isoquinolinesulfonamide hydrochloride
Purity: ≥97% (HPLC)
Potent and selective SETD7 inhibitor

Highly potent DOT1L inhibitor

Chemical Name: 7-[5-Deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Purity: ≥98% (HPLC)
Highly potent DOT1L inhibitor

Potent and selective type I PRMT inhibitor

Chemical Name: N1-Methyl-N1-[[4-[4-(1-methylethoxy)phenyl]-1H-pyrrol-3-yl]methyl]-1,2-ethanediamine dihydrochloride
Purity: ≥98% (HPLC)
Potent and selective type I PRMT inhibitor

Potent WDR5/MLL interaction inhibitor

Chemical Name: 1-[[(2S)-5-[(Aminoiminomethyl)amino]-2-[[2-ethyl-2-[(2-methyl-1-oxopropyl)amino]-1-oxobutyl]amino]-1-oxopentyl]amino]-N-[bis(4-fluorophenyl)methyl]-cyclopentanecarboxamide trifluoroacetate
Purity: ≥95% (HPLC)
Potent WDR5/MLL interaction inhibitor

Potent and selective PRMT5 inhibitor

Chemical Name: N-[(2S)-3-(3,4-Dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]-6-(3-oxetanylamino)-4-pyrimidinecarboxamide
Purity: ≥98% (HPLC)
Potent and selective PRMT5 inhibitor

Potent and selective EED inhibitor

Chemical Name: N-(2-Furanylmethyl)-8-[4-(methylsulfonyl)phenyl]-1,2,4-triazolo[4,3-c]pyrimidin-5-amine
Purity: ≥98% (HPLC)
Potent and selective EED inhibitor

SUV39H1 inhibitor

Chemical Name: (3S,3'S,5aR,5aR,10bR,10'bR,11aS,11'aS)-2,2',3,3',5a,5'a,6,6'-octahydro-3,3'-bis(hydroxymethyl)-2,2'-dimethyl-[10b,10'b(11H,11'H)-bi3,11a-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole]-1,1',4,4'-tetrone
Purity: ≥95% (HPLC)
SUV39H1 inhibitor

Potent and selective allosteric inhibitor of PRMT3

Chemical Name: 1-(Isoquinolin-6-yl)-3-[2-oxo-2-(pyrrolidin-1-yl)ethyl] urea
Purity: ≥98% (HPLC)
Potent and selective allosteric inhibitor of PRMT3

Negative control of (R)-PFI 2 hydrochloride (Cat. No. 4892)

Chemical Name: 8-Fluoro-1,2,3,4-tetrahydro-N-[(1S)-2-oxo-2-(1-pyrrolidinyl)-1-[[3-(trifluoromethyl)phenyl]methyl]ethyl]-6-isoquinolinesulfonamide hydrochloride
Purity: ≥97% (HPLC)
Negative control of (R)-PFI 2 hydrochloride (Cat. No. 4892)

Negative control of SGC 707 (Cat. No. 5367)

Chemical Name: N-2-Naphthalenyl-N'-[2-oxo-2-(1-pyrrolidinyl)ethyl]urea
Purity: ≥98% (HPLC)
Negative control of SGC 707 (Cat. No. 5367)

Selective PRMT5 Degrader (PROTAC®)

Chemical Name: N-((S)-3-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-((1-((S)-19-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidine-1-carbonyl)-20,20-dimethyl-17-oxo-3,6,9,12,15-pentaoxa-18-azahenicosanoyl)azetidin-3-yl)amino)pyrimidine-4-carboxamide
Purity: ≥98% (HPLC)
Selective PRMT5 Degrader (PROTAC®)

WDR5 antagonist

Chemical Name: 3-[(3-Methoxybenzoyl)amino]-4-(4-methyl-1-piperazinyl)benzoic acid methyl ester
Purity: ≥98% (HPLC)
WDR5 antagonist

High affinity and selective WDR5 antagonist

Chemical Name: N-[2-(4-Methylpiperazin-1-yl)-5-[3-(morpholin-4-ylmethyl)phenyl]phenyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide
Purity: ≥98% (HPLC)
High affinity and selective WDR5 antagonist
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