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38 results for "DNA, RNA and Protein Synthesis Inhibitors" in Products

DNA, RNA and Protein Synthesis Inhibitors Products

RNA, DNA and protein synthesis are fundamental processes necessary for all life.

RNA synthesis (transcription) begins by uncoiling a section of DNA that will be used as the template. RNA polymerase binds to a promoter sequence and initiates separation of the DNA double helix. Complementary ribonucleotides align and RNA polymerase catalyzes their polymerization. The newly synthesized RNA strand undergoes post-transcriptional processing before it leaves the nucleus.

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Protein synthesis inhibitor

Chemical Name: 3'-[α-Amino-p-methoxyhydrocinnamamido]-3'-deoxy-N,N-dimethyladenosine dihydrochloride
Purity: ≥98% (HPLC)
Protein synthesis inhibitor

DNA cross-linking antitumor agent

Alternate Names: Eloxatin
Chemical Name: Oxalato[(1R-trans)-1,2-cyclohexanediamine]platinum(II)
Purity: ≥98% (HPLC)
DNA cross-linking antitumor agent

Inhibitor of protein synthesis

Chemical Name: 4-[2-(3,5-Dimethyl-2-oxo-cyclohexyl)-2-hydroxyethyl]-2,6-piperidinedione
Purity: ≥97% (HPLC)
Inhibitor of protein synthesis

Purine analog; inhibits DNA synthesis

Chemical Name: 9-β-D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine
Purity: ≥98% (HPLC)
Purine analog; inhibits DNA synthesis

Nucleoside analog; inhibits DNA replication

Alternate Names: Cytosine b-D-arabinofuranoside
Chemical Name: 4-Amino-1-β-D-arabinofuranosyl-2(1H)-pyrimidinone
Purity: ≥98% (HPLC)
Nucleoside analog; inhibits DNA replication

DNA cross-linking antitumor agent

Alternate Names: Ametycine
Chemical Name: [1aS-(1aα,8β,8aα,8bα)]-6-Amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione
Purity: ≥98% (HPLC)
DNA cross-linking antitumor agent

Potent protein synthesis inhibitor

Alternate Names: Dehydrodidemnin B,DDB
Purity: ≥98% (HPLC)
Potent protein synthesis inhibitor

Inhibits RNA polymerase

Chemical Name: 2-Amino-(N,N)-1-bis(hexadecahydro-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentaoxo-1H-pyrrolo[2,1]-[1,4,7,10,13] oxatetraazacyclohexadecin-10-yl)-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide
Purity: ≥95% (HPLC)
Inhibits RNA polymerase

DNA synthesis inhibitor

Chemical Name: (+)-2'-Deoxy-2',2'-difluorocytidine hydrochloride
Purity: ≥98% (HPLC)
DNA synthesis inhibitor

RNA synthesis inhibitor

Chemical Name: 3'-Deoxyadenosine
Purity: ≥98% (HPLC)
RNA synthesis inhibitor

Inhibitor of protein synthesis; antileukemic agent

Chemical Name: Cephalotaxine 4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate
Purity: ≥98% (HPLC)
Inhibitor of protein synthesis; antileukemic agent

Antibiotic; inhibits protein, DNA and RNA synthesis in gram-positive bacteria

Alternate Names: LY 146032
Chemical Name: N-(1-Oxodecyl)-L-tryptophyl-D-asparaginyl-L-α-aspartyl-L-threonylglycyl-L-ornithinyl-L-α-aspartyl-D-alanyl-L-α-aspartylglycyl-D-seryl-(3R)-3-methyl-L-α-glutamyl-α,2-diamino-γ-oxo-benzene butanoic acid (13-4) lactone
Purity: ≥95% (HPLC)
Antibiotic; inhibits protein, DNA and RNA synthesis in gram-positive bacteria

Inhibitor of DNA and RNA polymerase

Chemical Name: (1S)-5-Deoxy-1-C-[(2S,3S)-7-[[2,6-dideoxy-3-O-(2,6-dideoxy-β-D-arabino-hexopyranosyl)-β-D-arabino-hexopyranosyl]oxy]-3-[(O-2,6-dideoxy-3-C-methyl-β-D-ribo-hexopyranosyl-(1.fwdarw.3)-O-2,6-dideoxy-β-D-lyxo-hexopyranosyl-(1.fwdarw.3)-2,6-dideoxy-β-D-arabino-hexopyranosyl)oxy]-1,2,3,4-tetrahydro-5,10-dihydroxy-6-methyl-4-oxo-2-anthracenyl]-1-O-methyl-D-threo-2-pentulose
Purity: ≥95% (HPLC)
Inhibitor of DNA and RNA polymerase

Antibiotic; inhibits bacterial DNA synthesis

Chemical Name: (S)-3,6-Diamino-N-((3S,9S,12S,15S,Z)3((2R,4S)-6-amino-4-hydroxy-1,2,3,4-tetrahydropyridin-2-yl)-9,12-bis(hydroxymethyl)-2,5,8,11,14-pentaoxo-6-(ureidomethylene)-1,4,7,10,13-pentaazacyclohexadecan-15-yl)hexanamide disulfate
Antibiotic; inhibits bacterial DNA synthesis

JNK, SAPK and p38 activator

Chemical Name: (2R,3S,4S)-2-[(4-Methoxyphenyl)methyl]-3,4-pyrrolidinediol 3-acetate
Purity: ≥98% (HPLC)
JNK, SAPK and p38 activator

DNA synthesis inhibitor. Induces pulmonary inflammation and fibrosis

Alternate Names: NSC125066
Purity: ≥90% (HPLC)
DNA synthesis inhibitor. Induces pulmonary inflammation and fibrosis

Inhibitor of RNA helicase A (RHA)

Chemical Name: 4,7-Dichloro-1,3-dihydro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-2H-indol-2-one
Purity: ≥98% (HPLC)
Inhibitor of RNA helicase A (RHA)

Thymidylate synthetase inhibitor

Alternate Names: 5-FU
Chemical Name: 5-Fluoro-2,4-(1H,3H)-pyrimidinedione
Purity: ≥98% (HPLC)
Thymidylate synthetase inhibitor

DNA polymerase α, δ and ε inhibitor

Chemical Name: (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-Tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-8,11a-methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol
Purity: ≥98% (HPLC)
DNA polymerase α, δ and ε inhibitor

Thymidine analog for labeling DNA; can be linked to a fluorophore by click chemistry

Chemical Name: 5-ethynyl-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
Purity: ≥95% (HPLC)
Thymidine analog for labeling DNA; can be linked to a fluorophore by click chemistry

DNA topoisomerase II inhibitor

Alternate Names: Daunomycin
Chemical Name: (8S,10S)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyransoyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione hydrochloride
Purity: ≥98% (HPLC)
DNA topoisomerase II inhibitor

Antibiotic; inhibits bacterial DNA synthesis

Alternate Names: CP 99219
Chemical Name: 7-[(1α,5α,6α)-6-Amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid mesylate
Purity: ≥98% (HPLC)
Antibiotic; inhibits bacterial DNA synthesis

Inhibits RNAPII-mediated transcription; antitumor, anti-inflammatory and immunosuppressive

Chemical Name: (3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-3b,4,4a,6,6a,7a,7b,8b,9,10-Decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one
Purity: ≥98% (HPLC)
Inhibits RNAPII-mediated transcription; antitumor, anti-inflammatory and immunosuppressive

RNA polymerase I inhibitor; also p53 pathway activator

Chemical Name: N-[2-(Dimethylamino)ethyl]-12-oxo-12H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide
Purity: ≥98% (HPLC)
RNA polymerase I inhibitor; also p53 pathway activator

Purine nuceloside analog; inhibits DNA synthesis

Alternate Names: GW 506U78
Chemical Name: 9-β-D-Arabinofuranosyl-6-methoxy-9H-purin-2-amine
Purity: ≥98% (HPLC)
Purine nuceloside analog; inhibits DNA synthesis
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