Aphidicolin
Tocris Bioscience, part of Bio-Techne | Catalog # 5736
DNA polymerase α, δ and ε inhibitor
Key Product Details
Description
DNA polymerase α, δ and ε inhibitor
Product Description
Aphidicolin is a DNA polymerase α, δ and ε inhibitor. Exhibits selectivity over DNA polymerase β and γ. Antimitotic, antibiotic and antiviral.Product Specifications
Molecular Weight
338.48
Formula
C20H34O4
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(3R,4R,4aR,6aS,8R,9R,11aS,11bS)-Tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-8,11a-methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol
CAS Number
38966-21-1
PubChem ID
457964
InChI Key
NOFOAYPPHIUXJR-APNQCZIXSA-N
SMILES
OC[C@@]1(O)CC[C@@]23[C@](CC[C@]4([H])[C@]3(C)CC[C@@H](O)[C@@]4(C)CO)([H])C[C@@H]1C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 8.46 | 25 |
Preparing Stock Solutions
for Aphidicolin
The following data is based on the product molecular weight 338.48
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 11.82 mL | 59.09 mL | 118.18 mL |
| 1.25 mM | 2.36 mL | 11.82 mL | 23.64 mL |
| 2.5 mM | 1.18 mL | 5.91 mL | 11.82 mL |
| 12.5 mM | 0.24 mL | 1.18 mL | 2.36 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Bucknall Antiviral effects of aphidicolin, a new antibiotic produced by Cephalosporium aphidicola. Antimicrob.Agents Chemother. 1973 PMID: 4357181
- Syväoja DNA polymerases α, δ, and ε: three distinct enzymes from HeLa cells. Proc.Natl.Acad.Sci.U.S.A. 1990 PMID: 1975694
- Spadari Control of DNA replication and cell proliferation in eukaryotes by aphidicolin. Toxicol.Pathol. 1984 PMID: 11478315
Product Specific Notices for Aphidicolin
For research use only
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