BMH 21

Tocris Bioscience, part of Bio-Techne | Catalog # 5417

RNA polymerase I inhibitor; also p53 pathway activator
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Key Product Details

Description

RNA polymerase I inhibitor; also p53 pathway activator

View all RNA/DNA Polymerase Inhibitors »

Product Description

BMH 21 is a p53 pathway activator; induces expression of p53 target genes. Also RNA polymerase 1 inhibitor; promotes degradation of RPA194. Reduces viability of multiple tumor cell lines and attenuates tumor growth of A375 melanoma cell xenografts in mice.

Product Specifications

Molecular Weight

360.41

Formula

C21H20N4O2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-[2-(Dimethylamino)ethyl]-12-oxo-12H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide

CAS Number

896705-16-1

PubChem ID

3508054

InChI Key

BXYDVWIAGDJBEC-UHFFFAOYSA-N

SMILES

O=C2N4C(C(C(NCCN(C)C)=O)=CC=C4)=NC(C2=C3)=CC1=C3C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 1.8 5 with gentle warming

Preparing Stock Solutions for BMH 21

The following data is based on the product molecular weight 360.41

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 55.49 mL 277.46 mL 554.92 mL
0.25 mM 11.10 mL 55.49 mL 110.98 mL
0.5 mM 5.55 mL 27.75 mL 55.49 mL
2.5 mM 1.11 mL 5.55 mL 11.10 mL

Calculators

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Reconstitution Calculator

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Product Documents for BMH 21

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for BMH 21

For research use only

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