Nelarabine

Name: Nelarabine
Brand: Tocris Bioscience
SKU: 6359

Tocris Bioscience a Bio-Techne Brand

Catalog # 6359

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Key Product Details

Description:	Purine nuceloside analog; inhibits DNA synthesis
Alternative Names:	GW 506U78
Chemical Name:	9-β-D-Arabinofuranosyl-6-methoxy-9H-purin-2-amine
Purity:	≥98% (HPLC)
Molecular Weight:	297.27

View Full Technical Details for Nelarabine

Biological Activity for Nelarabine

Nelarabine is a nucleoside analog. Metabolized by adenosine deaminase to active metabolite, arabinofuranosylguanine (ara-G). Inhibits DNA synthesis and induces apoptosis. Inhibits growth of human T cell lymphoblastic leukemia cells in vitro and in vivo.

Compound Libraries for Nelarabine

Nelarabine is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Nelarabine

M. Wt	297.27
Formula	C₁₁H₁₅N₅O₅
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	121032-29-9
PubChem ID	3011155
InChi Key	IXOXBSCIXZEQEQ-UHTZMRCNSA-N
Smiles	COC1=C2C(N([C@@H]3O[C@H](CO)[C@@H](O)[C@@H]3O)C=N2)=NC(N)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Nelarabine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	29.73	100
	water	2.97	10 with gentle warming

Preparing Stock Solutions for Nelarabine

The following data is based on the product molecular weight 297.27.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.36 mL	16.82 mL	33.64 mL
5 mM	0.67 mL	3.36 mL	6.73 mL
10 mM	0.34 mL	1.68 mL	3.36 mL
50 mM	0.07 mL	0.34 mL	0.67 mL

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Reconstitution Calculator

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References for Nelarabine

References are publications that support the biological activity of the product.

Reilly and Kisor Profile of nelarabine: use in the treatment of T-cell acute lymphoblastic leukemia. OncoTargets Ther. 2009 PMID: 20616909
Beesley In vitro cytotoxicity of nelarabine, clofar. and flavopiridol in paediatric acute lymphoblastic leukaemia. Br.J.Haematol. 2007 PMID: 17391490
Lambe 2-Amino-6-methoxypurine arabinoside: an agent for T-cell malignancies. Cancer Res. 1995 PMID: 7614470

Citations for Nelarabine

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