Plitidepsin

Name: Plitidepsin
Brand: Tocris Bioscience
SKU: 7416

Tocris Bioscience, part of Bio-Techne | Catalog # 7416

COA / SDS

Potent protein synthesis inhibitor

Key Product Details

Description:	Potent protein synthesis inhibitor
Alternative Names:	Dehydrodidemnin B,DDB
Purity:	≥98% (HPLC)
Molecular Weight:	1110.36

View Full Technical Details for Plitidepsin

Technical Data
Citations

Biological Activity for Plitidepsin

Plitidepsin (dehydrodidemnin B) is a potent inhibitor of protein synthesis, blocker of G1 and G2 phases in cell cycle and potent antiviral against SARS-CoV-2 in hACE2-293T, Vero E6 cells and models of pneumocyte-like cells (IC₉₀ values are 0.88 nM, 1.76 nM and 3.14 nM, respectively). Plitidepsin also inhibits eukaryotic translation elongation factor 1 alpha 1 (eEF1A) (K_D = 80 nM).

In vitro, it inhibits induction of ornithine decarboxylase (ODC), which is essential for cell transformation and proliferation.

In vivo, daily administration of Plitidepsin on mice affected by Ehrlich carcinoma duplicated the animal life-span and decreased the total number of tumor cells by 70-90%. Plitidepsin also reduces viral SARS-CoV-2 replication in the lungs (mouse).

It is recommended to prepare stock solutions in DMSO.

Technical Data for Plitidepsin

M. Wt	1110.36
Formula	C₅₇H₈₇N₇O₁₅
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	137219-37-5
PubChem ID	9812534
InChi Key	UUSZLLQJYRSZIS-LXNNNBEUSA-N
Smiles	[H][C@@]12CCCN1C([C@](CC(C)C)(NC([C@H](C([C@H](C(C)C)OC(C[C@@H]([C@](NC([C@H]([C@H](OC([C@@H](N(C2=O)C)CC3=CC=C(C=C3)OC)=O)C)NC([C@H](N(C([C@@H]4CCCN4C(C(C)=O)=O)=O)C)CC(C)C)=O)=O)([C@H](CC)C)[H])O)=O)=O)C)=O)[H])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Plitidepsin

References are publications that support the biological activity of the product.

Reuschl Host-directed therapies against early-lineage SARS-CoV-2 retain efficacy against B.1.1.7 variant. bioRxiv 2021 PMID: 33501437
Losada Translation elongation factor eEF1A2 is a novel anticancer target for the marine natural product plitidepsin. Sci.Rep. 2016 PMID: 27713531
White Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A. Science 2021 PMID: 33495306
Urdiales Antiproliferative effect of dehydrodidemnin B (DDB), a depsipeptide isolated from Mediterranean tunicates. Cancer Letters 1996 PMID: 8603376

Plitidepsin

Tocris Bioscience, part of Bio-Techne | Catalog # 7416

Key Product Details

Biological Activity for Plitidepsin

Technical Data for Plitidepsin

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Plitidepsin

Product Documents for Plitidepsin

COA

Certificate of Analysis

SDS

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