Plitidepsin New

Name: Plitidepsin
Brand: Tocris Bioscience
SKU: 7416

Tocris Bioscience, part of Bio-Techne | Catalog # 7416

COA / SDS

Potent protein synthesis inhibitor

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Technical Data
Citations & Reviews

Product Description
Product Specifications
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Potent protein synthesis inhibitor

Alternative Names

Dehydrodidemnin B,DDB

View all DNA, RNA and Protein Synthesis Inhibitors »

Product Description

Plitidepsin (dehydrodidemnin B) is a potent inhibitor of protein synthesis, blocker of G1 and G2 phases in cell cycle and potent antiviral against SARS-CoV-2 in hACE2-293T, Vero E6 cells and models of pneumocyte-like cells (IC₉₀ values are 0.88 nM, 1.76 nM and 3.14 nM, respectively). Plitidepsin also inhibits eukaryotic translation elongation factor 1 alpha 1 (eEF1A) (K_D = 80 nM). In vitro, it inhibits induction of ornithine decarboxylase (ODC), which is essential for cell transformation and proliferation. In vivo, daily administration of Plitidepsin on mice affected by Ehrlich carcinoma duplicated the animal life-span and decreased the total number of tumor cells by 70-90%. Plitidepsin also reduces viral SARS-CoV-2 replication in the lungs (mouse).

It is recommended to prepare stock solutions in DMSO.

Product Specifications

Molecular Weight

1110.36

Formula

C₅₇H₈₇N₇O₁₅

Storage

Store at -20°C

Purity

≥98% (HPLC)

CAS Number

137219-37-5

PubChem ID

9812534

InChI Key

UUSZLLQJYRSZIS-LXNNNBEUSA-N

SMILES

[H][C@@]12CCCN1C([C@](CC(C)C)(NC([C@H](C([C@H](C(C)C)OC(C[C@@H]([C@](NC([C@H]([C@H](OC([C@@H](N(C2=O)C)CC3=CC=C(C=C3)OC)=O)C)NC([C@H](N(C([C@@H]4CCCN4C(C(C)=O)=O)=O)C)CC(C)C)=O)=O)([C@H](CC)C)[H])O)=O)=O)C)=O)[H])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

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Reconstitution Calculator

Background References

References are publications that support the biological activity of the product.

Reuschl Host-directed therapies against early-lineage SARS-CoV-2 retain efficacy against B.1.1.7 variant. bioRxiv 2021 PMID: 33501437
Losada Translation elongation factor eEF1A2 is a novel anticancer target for the marine natural product plitidepsin. Sci.Rep. 2016 PMID: 27713531
White Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A. Science 2021 PMID: 33495306
Urdiales Antiproliferative effect of dehydrodidemnin B (DDB), a depsipeptide isolated from Mediterranean tunicates. Cancer Letters 1996 PMID: 8603376