Homoharringtonine

Name: Homoharringtonine
Brand: Tocris Bioscience
SKU: 1416
Rating: 5 (1 reviews)

Catalog # 1416 | Tocris Bioscience a Bio-Techne Brand

(1)

Citations (3)

COA / SDS

Inhibitor of protein synthesis; antileukemic agent

Key Product Details

Description:	Inhibitor of protein synthesis; antileukemic agent
Chemical Name:	Cephalotaxine 4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate
Purity:	≥98% (HPLC)
Molecular Weight:	545.63

View Full Technical Details for Homoharringtonine

Biological Activity for Homoharringtonine

Homoharringtonine is an inhibitor of protein synthesis. Blocks elongation phase of translation by binding to the 60-S ribosome subunit. Antileukemic. Inhibits SARS-CoV-2 infection in vitro (IC₅₀ = 2.55 μM).

Technical Data for Homoharringtonine

M. Wt	545.63
Formula	C₂₉H₃₉NO₉
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	26833-87-4
PubChem ID	285033
InChi Key	HYFHYPWGAURHIV-JFIAXGOJSA-N
Smiles	O=C([C@](CCCC(O)(C)C)(O)CC(OC)=O)O[C@@H]1C(OC)=C[C@@](N(CCC5)CCC2=CC4=C(OCO4)C=C23)5[C@]31[H]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Homoharringtonine

	Solvent	Max Conc. mM
Solubility
	DMSO	100
	ethanol	50

Preparing Stock Solutions for Homoharringtonine

The following data is based on the product molecular weight 545.63.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.83 mL	9.16 mL	18.33 mL
5 mM	0.37 mL	1.83 mL	3.67 mL
10 mM	0.18 mL	0.92 mL	1.83 mL
50 mM	0.04 mL	0.18 mL	0.37 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Homoharringtonine

References are publications that support the biological activity of the product.

Choy Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro. Antiviral Res. 2020 PMID: 32251767
Cai Apoptotic response to homoharringtonine in human wt p53 leukemic cells is independent of reactive oxygen species generation and implicates Bax translocation, mitochondrial cytochrome c release and caspase activation. Leukemia 2001 PMID: 11368358
Zhou Homoharringtonine: an effective new natural product in cancer chemotherapy. Bull.Cancer 1995 PMID: 8745664
Fresno Inhibition of translation in eukaryotic systems by harringtonine. Eur.J.Biochem. 1977 PMID: 319998

Citations for Homoharringtonine (3)

Showing 1 - 3 of 3 citations Showing All

Search Title:

Citations are publications that use Bio-Techne products. Selected citations for Homoharringtonine include:

Paige et al. (2019) AMPK activation regulates P-body dynamics in mouse sensory neurons in vitro and in vivo. Neurobiol Pain. 5
PMID: 31080914
Akef et al. (2015) Splicing promotes the nuclear export of β-globin mRNA by overcoming nuclear retention elements. Cell J. 21:1908
PMID: 26362019
Xia et al. (2013) Identification of repurposed small molecule drugs for chordoma therapy. Cancer Biol Ther. 14:638
PMID: 23792643

There are no citations that match your criteria.

Showing 1 - 3 of 3 citations Showing All

Customer Reviews for Homoharringtonine (1)

5 out of 5

1 customer rating

5 stars

100%

4 stars

3 stars

2 stars

1 star

Customer Images

Showing 1 - 1 of 1 review Showing All

Filter By:

Homoharringtonine completely kills melanoma cell line at micromolar concentrations

Name: Anonymous

Species: Human

Assay Type: In Vitro

Cell Line/Tissue: SK-MEL-28

Used for killing assay for in vitro cell culture. Cells were cultured for 24 hours before the addition of the compound into the media at low micromolar concentrations (indicated by the arrow).

There are no reviews that match your criteria.