Halofuginone hydrobromide

Tocris Bioscience, part of Bio-Techne | Catalog # 1993

High affinity competitive prolyl-tRNA synthetase inhibitor
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Key Product Details

Description

High affinity competitive prolyl-tRNA synthetase inhibitor

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Product Description

Halofuginone hydrobromide is a high affinity competitive prolyl-tRNA synthetase inhibitor (Ki = 18.3 nM). Blocks expression of MMP2. Inhibits ECM invasion in vitro and lung metastasis by bladder cancer cells in mice. Inhibits the development of Th17-driven autoimmunity in a mouse model of multiple sclerosis by activating the amino acid response (AAR) pathway. Also antiparasitic.

Product Specifications

Molecular Weight

495.59

Formula

C16H17BrClN3O3.HBr

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(2R*,3S*)-7-Bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-4-3H-quinazolinone hydrobromide

CAS Number

64924-67-0

PubChem ID

400771

InChI Key

SJUWEPZBTXEUMU-LDXVYITESA-N

SMILES

BrC1=CC2=C(C(N(CC(C[C@@H]3[C@H](O)CCCN3)=O)C=N2)=O)C=C1Cl.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 49.56 100

Preparing Stock Solutions for Halofuginone hydrobromide

The following data is based on the product molecular weight 495.59

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.02 mL 10.09 mL 20.18 mL
5 mM 0.40 mL 2.02 mL 4.04 mL
10 mM 0.20 mL 1.01 mL 2.02 mL
50 mM 0.04 mL 0.20 mL 0.40 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Halofuginone hydrobromide

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Halofuginone hydrobromide

For research use only

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