Cordycepin
Tocris Bioscience, part of Bio-Techne | Catalog # 2294
RNA synthesis inhibitor
Key Product Details
Description
RNA synthesis inhibitor
Product Description
Cordycepin is a nucleoside analog that acts as an anticancer and antifungal agent. Can be converted to 3'-deoxyadenosine triphosphate (3'-dATP), which inhibits ATP-dependent DNA synthesis. Inhibits growth of various tumor cells in vitro.Product Specifications
Molecular Weight
251.24
Formula
C10H13N5O3
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
3'-Deoxyadenosine
CAS Number
73-03-0
PubChem ID
6303
InChI Key
OFEZSBMBBKLLBJ-BAJZRUMYSA-N
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]3O[C@H](CO)C[C@H]3O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 25.12 | 100 |
Preparing Stock Solutions
for Cordycepin
The following data is based on the product molecular weight 251.24
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.98 mL | 19.90 mL | 39.80 mL |
| 5 mM | 0.80 mL | 3.98 mL | 7.96 mL |
| 10 mM | 0.40 mL | 1.99 mL | 3.98 mL |
| 50 mM | 0.08 mL | 0.40 mL | 0.80 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Sugar and McCaffrey Antifungal activity of 3'-deoxyadenosine (cordycepin). Antimicrob.Agents Chemother. 1998 PMID: 9624488
- Kodama Antileukemic activity and mechanism of action of cordycepin against terminal deoxynucleotidyl transferase-positive (TdT+) leukemic cells. Biochem.Pharmacol. 2000 PMID: 10609556
- Gumport and Edelhei The synthesis of 3'-dATP and its use as an inhibitor of ATP-dependent DNA synthesis in toluene-treated Escherichia coli. Biochemistry 1976 PMID: 779831
Product Specific Notices for Cordycepin
For research use only
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