YK 4-279
Tocris Bioscience, part of Bio-Techne | Catalog # 4067
Inhibitor of RNA helicase A (RHA)
Key Product Details
Description
Inhibitor of RNA helicase A (RHA)
Product Description
YK 4-279 is an inhibitor of RNA Helicase A (RHA) binding to the oncogenic transciption factor EWS-FLI1. Inhibits Ewing's sarcoma family tumor (ESFT) cell growth; induces apoptosis.Product Specifications
Molecular Weight
366.20
Formula
C17H13Cl2NO4
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
4,7-Dichloro-1,3-dihydro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-2H-indol-2-one
CAS Number
1037184-44-3
PubChem ID
44632017
InChI Key
HLXSCTYHLQHQDJ-UHFFFAOYSA-N
SMILES
O=C2NC1=C(Cl)C=CC(Cl)=C1C(CC(C3=CC=C(OC)C=C3)=O)2O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.62 | 100 |
Preparing Stock Solutions
for YK 4-279
The following data is based on the product molecular weight 366.20
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.73 mL | 13.65 mL | 27.31 mL |
| 5 mM | 0.55 mL | 2.73 mL | 5.46 mL |
| 10 mM | 0.27 mL | 1.37 mL | 2.73 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.55 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Erkizan Small molecule selected to disrupt oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits Ewing's sarcoma. Nat.Med. 2009 PMID: 19584866
Product Specific Notices for YK 4-279
For research use only
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