Cytarabine

Name: Cytarabine
Brand: Tocris Bioscience
SKU: 4520
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4520

(1)

Citations (35)

COA / SDS

Nucleoside analog; inhibits DNA replication

Key Product Details

Description:	Nucleoside analog; inhibits DNA replication
Alternative Names:	Cytosine b-D-arabinofuranoside
Chemical Name:	4-Amino-1-β-D-arabinofuranosyl-2(1H)-pyrimidinone
Purity:	≥98% (HPLC)
Molecular Weight:	243.22

View Full Technical Details for Cytarabine

Technical Data
Citations / Reviews (1)

Biological Activity for Cytarabine

Cytarabine is a nucleoside analog of deoxycytidine; inhibits DNA replication by incorporating into DNA (IC₅₀ = 0.04 μM in L1210 and CEM cell lines). Displays no inhibitory effects on RNA synthesis. Causes S phase cell cycle arrest in ML-1 cell lines; cytotoxic in L5817Y leukemia cells. Antineoplastic and antileukemic agent.

Technical Data for Cytarabine

M. Wt	243.22
Formula	C₉H₁₃N₃O₅
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	147-94-4
PubChem ID	114682
InChi Key	UHDGCWIWMRVCDJ-STUHELBRSA-N
Smiles	O[C@@H]1[C@@H](CO)OC(N2C=CC(N)=NC2=O)[C@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Cytarabine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	24.32	100
	DMSO	12.16	50

Preparing Stock Solutions for Cytarabine

The following data is based on the product molecular weight 243.22.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.11 mL	20.56 mL	41.12 mL
5 mM	0.82 mL	4.11 mL	8.22 mL
10 mM	0.41 mL	2.06 mL	4.11 mL
50 mM	0.08 mL	0.41 mL	0.82 mL

Molarity Calculator

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Reconstitution Calculator

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References for Cytarabine

References are publications that support the biological activity of the product.

Breistøl Antitumor activity of P-4055 (elaidic acid-cytarabine) compared to cytar. in metastatic and s.c. human tumor xenograft models. Cancer Res. 1999 PMID: 10383159
Yang Effect of cytar. upon metabolism of phospholipids in leukemia L5178Y cells. Acta Pharmacol. Sin. 1986 PMID: 2954403
Sampath Pharmacodynamics of cytar. alone and in combination with 7-hydroxystaurosporine (UCN-01) in AML blasts in vitro and during a clinical trial. Blood. 2006 PMID: 16293603

Product Documents for Cytarabine

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Cytarabine, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov