Viomycin

Name: Viomycin
Brand: Tocris Bioscience
SKU: 3787
Rating: 4 (1 reviews)

Catalog # 3787 | Tocris Bioscience a Bio-Techne Brand

(1)

Citations (5)

COA / SDS

Antibiotic; inhibits bacterial DNA synthesis

Key Product Details

Description:	Antibiotic; inhibits bacterial DNA synthesis
Chemical Name:	(S)-3,6-Diamino-N-((3S,9S,12S,15S,Z)3((2R,4S)-6-amino-4-hydroxy-1,2,3,4-tetrahydropyridin-2-yl)-9,12-bis(hydroxymethyl)-2,5,8,11,14-pentaoxo-6-(ureidomethylene)-1,4,7,10,13-pentaazacyclohexadecan-15-yl)hexanamide disulfate
Molecular Weight:	881.85

View Full Technical Details for Viomycin

Technical Data
Citations (5) / Reviews (1)

Biological Activity for Viomycin

Viomycin is a member of the tuberactinomycin family of antibiotics. Inhibits group I intron splicing and prokaryotic protein synthesis. Freezes bacterial ribosomes in either the pre- or post-translational state. Facilitates trans-cleavage of the Neurospora VS ribozyme.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for Viomycin

M. Wt	881.85
Formula	C₂₅H₄₃N₁₃O₁₀.2H₂SO₄
Storage	Store at -20°C
PubChem ID	90488875
InChi Key	HMKHTQGEDRQEOM-IGZVKJTASA-N
Smiles	O[C@H](N1)C[C@@H]([C@H](C(NC[C@@H](C(N[C@@H](CO)C(N[C@H](C(N2)=O)CO)=O)=O)NC(C[C@@H](N)CCCN)=O)=O)NC(/C2=C/NC(N)=O)=O)NC1=N.OS(O)(=O)=O.OS(O)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Viomycin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	66.14	75

Preparing Stock Solutions for Viomycin

The following data is based on the product molecular weight 881.85.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	1.51 mL	7.56 mL	15.12 mL
3.75 mM	0.30 mL	1.51 mL	3.02 mL
7.5 mM	0.15 mL	0.76 mL	1.51 mL
37.5 mM	0.03 mL	0.15 mL	0.30 mL

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Reconstitution Calculator

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References for Viomycin

References are publications that support the biological activity of the product.

Ermolenko The antibiotic vio. traps the ribosome in an intermediate state of translocation. Nat.Struct.Mol.Biol. 2007 PMID: 17515906
Schroeder Modulation of RNA function by aminoglycoside antibiotics. EMBO J. 2000 PMID: 10619838
Hausner The allosteric three-site model for the ribosomal elongation cycle. J.Biol.Chem. 1988 PMID: 2843509

Citations for Viomycin (5)

Showing 1 - 5 of 5 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Viomycin include:

Matilde E et al. (2019) Common Metabolic Pathways Implicated in Resistance to Chemotherapy Point to a Key Mitochondrial Role in Breast Cancer. Mol Cell Proteomics. 18:231-244
PMID: 33451433
Abad et al. (2018) Common metabolic pathways implicated in resistance to chemotherapy point to a key mitochondrial role in breast cancer. Mol Cell Proteomics. 2018;
PMID: 30373788
Freihofer et al. (2016) Nonmutational compensation of the fitness cost of antibiotic resistance in mycobacteria by overexpression of tlyA rRNA methylase. RNA. 22:1836
PMID: 27698071
Samokhvalov et al. (2015) PPARδ signaling mediates the cytotoxicity of DHA in H9c2 cells. PLoS One. 232:44105
PMID: 25300478
Akbergenov et al. (2011) Molecular basis for the selectivity of antituberculosis compounds capreo. and vio. Antimicrob Agents Chemother. 55:4712
PMID: 21768509

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Customer Reviews for Viomycin (1)

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Viomycin and streptomycin were compared in inhibition of bacterial protein production

Name: Anonymous

Species: Human

Viomycin and streptomycin were compared in inhibition of bacterial protein production.Cross-resistance between streptomycin and other aminoglycosides and polypeptides observed.

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