Viomycin
Tocris Bioscience, part of Bio-Techne | Catalog # 3787
Antibiotic; inhibits bacterial DNA synthesis
Product Description
Viomycin is a member of the tuberactinomycin family of antibiotics. Inhibits group I intron splicing and prokaryotic protein synthesis. Freezes bacterial ribosomes in either the pre- or post-translational state. Facilitates trans-cleavage of the Neurospora VS ribozyme.Licensing Information
Sold for research purposes under agreement from Pfizer Inc.Product Specifications
Molecular Weight
881.85
Formula
C25H43N13O10.2H2SO4
Storage
Store at -20°C
Chemical Name
(S)-3,6-Diamino-N-((3S,9S,12S,15S,Z)3((2R,4S)-6-amino-4-hydroxy-1,2,3,4-tetrahydropyridin-2-yl)-9,12-bis(hydroxymethyl)-2,5,8,11,14-pentaoxo-6-(ureidomethylene)-1,4,7,10,13-pentaazacyclohexadecan-15-yl)hexanamide disulfate
PubChem ID
90488875
InChI Key
HMKHTQGEDRQEOM-IGZVKJTASA-N
SMILES
O[C@H](N1)C[C@@H]([C@H](C(NC[C@@H](C(N[C@@H](CO)C(N[C@H](C(N2)=O)CO)=O)=O)NC(C[C@@H](N)CCCN)=O)=O)NC(/C2=C/NC(N)=O)=O)NC1=N.OS(O)(=O)=O.OS(O)(=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 66.14 | 75 |
Preparing Stock Solutions
for Viomycin
The following data is based on the product molecular weight 881.85
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.75 mM | 1.51 mL | 7.56 mL | 15.12 mL |
| 3.75 mM | 0.30 mL | 1.51 mL | 3.02 mL |
| 7.5 mM | 0.15 mL | 0.76 mL | 1.51 mL |
| 37.5 mM | 0.03 mL | 0.15 mL | 0.30 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hausner The allosteric three-site model for the ribosomal elongation cycle. J.Biol.Chem. 1988 PMID: 2843509
- Schroeder Modulation of RNA function by aminoglycoside antibiotics. EMBO J. 2000 PMID: 10619838
- Ermolenko The antibiotic vio. traps the ribosome in an intermediate state of translocation. Nat.Struct.Mol.Biol. 2007 PMID: 17515906
Product Specific Notices for Viomycin
For research use only
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