alpha-2C Adrenergic R/ADRA2C: Small Molecules and Peptides
Alpha-2-adrenergic receptors, including ADRA2C, are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C receptors that have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Mouse studies have revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The ADRA2A subtype inhibited transmitter release at high stimulation frequencies, whereas the ADRA2C subtype modulated neurotransmission at lower levels of nerve activity.
16 results for "alpha-2C Adrenergic R/ADRA2C Small Molecules and Peptides" in Products
16 results for "alpha-2C Adrenergic R/ADRA2C Small Molecules and Peptides" in Products
alpha-2C Adrenergic R/ADRA2C: Small Molecules and Peptides
Alpha-2-adrenergic receptors, including ADRA2C, are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C receptors that have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Mouse studies have revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The ADRA2A subtype inhibited transmitter release at high stimulation frequencies, whereas the ADRA2C subtype modulated neurotransmission at lower levels of nerve activity.
Potent, highly selective α2 agonist. Active isomer of medetomidine (Cat. No. 5160)
| Alternate Names: | d-Medetomidine hydrochloride |
| Chemical Name: | 4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride |
| Purity: | ≥98% |
Non-selective 5-HT, dopamine, adrenalin and histamine receptor antagonist; antipsychotic agent
| Chemical Name: | (3aR*,12bR*)-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole maleate |
| Purity: | ≥98% (HPLC) |
Selective α2 antagonist
| Chemical Name: | 17α-Hydroxyyohimban-16α-carboxylic acid methyl ester hydrochloride |
| Purity: | ≥98% (HPLC) |
α2 agonist. Also I1 ligand
| Chemical Name: | 2-[(2,6-Dichlorophenyl)amino-2-imidazoline hydrochloride |
| Purity: | ≥98% (HPLC) |
Potent and highly selective α2 agonist
| Chemical Name: | 4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride |
| Purity: | ≥98% (HPLC) |
Potent and selective adrenergic α2B antagonist
| Chemical Name: | 1-[2-[[[3-(3,5-Dimethyl-4-isoxazolyl)imidazo[1,2-a]pyridin-7-yl]carbonyl]amino]ethyl]-4-(methylamino)pyridinium chloride |
| Purity: | ≥98% (HPLC) |
Potent, selective α2D antagonist
| Chemical Name: | 2-(2,3-Dihydro-2-methoxy-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-imidazole hydrochloride |
| Purity: | ≥98% (HPLC) |
Potent and non-selective β antagonist; also potent α1 antagonist
| Alternate Names: | BM 14190 |
| Chemical Name: | 1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol |
| Purity: | ≥98% (HPLC) |
Potent and selective α2 antagonist
| Chemical Name: | 6-Chloro-N-methyl-2,3,4,5-tetrahydro-1-H-3-benzazepine hydrochloride |
| Purity: | ≥98% (HPLC) |
Potent and selective α2 antagonist
| Chemical Name: | (8aR,12aS,13aS)-5,8,8a,9,10,11,12,12a,13,13a-dechydro-3-methoxy-12-(ethylsulfonyl)-6H-isoquino[2,1-g][1,6]naphthyridine hydrochloride |
| Purity: | ≥98% (HPLC) |
Selective α2 antagonist
| Chemical Name: | 5-(2-Ethyl-2,3-dihydro-1H-indene-2-yl)-1H-imidazole hydrochloride |
| Purity: | ≥98% (HPLC) |
α2 agonist. Water-soluble form of UK 14,304 (Cat. No. 0425)
| Chemical Name: | 5-Bromo-6-(2-imidazolin-2-ylamino)quinoxaline tartrate |
| Purity: | ≥98% (HPLC) |
α2 agonist
| Chemical Name: | 5-Bromo-6-(2-imidazolin-2-ylamino)quinoxaline |
Selective α2 agonist
| Alternate Names: | Azepexole |
| Chemical Name: | 6-Ethyl-5,6,7,8-tetrahydro-4H-oxazolo[4,5-d]azepin-2-amine dihydrochloride |
| Purity: | ≥98% (HPLC) |
α2 agonist
| Chemical Name: | 5-(Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine hydrochloride |
| Purity: | ≥98% (HPLC) |
Potent and selective α2C antagonist
| Chemical Name: | N-[4-(4-Methyl-1-piperazinyl)phenyl]-9-acridinamine dihydrochloride |
| Purity: | ≥98% (HPLC) |
