Atipamezole hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 2937
Selective α2 antagonist
Key Product Details
Description
Selective α2 antagonist
Product Description
Atipamezole hydrochloride is a selective α2-adrenergic receptor antagonist (Ki values are 1.1, 1.0, 0.89, 1300 and 6500 nM for α2A, α2B, α2C, α1A and α1B receptors respectively). Brain penetrant.Product Specifications
Molecular Weight
248.75
Formula
C14H16N2.HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
5-(2-Ethyl-2,3-dihydro-1H-indene-2-yl)-1H-imidazole hydrochloride
CAS Number
104075-48-1
PubChem ID
13649426
InChI Key
PCCVCJAQMHDWJY-UHFFFAOYSA-N
SMILES
CCC2(C3=CN=CN3)CC1=CC=CC=C1C2.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 24.87 | 100 | |
| DMSO | 24.87 | 100 |
Preparing Stock Solutions
for Atipamezole hydrochloride
The following data is based on the product molecular weight 248.75
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.02 mL | 20.10 mL | 40.20 mL |
| 5 mM | 0.80 mL | 4.02 mL | 8.04 mL |
| 10 mM | 0.40 mL | 2.01 mL | 4.02 mL |
| 50 mM | 0.08 mL | 0.40 mL | 0.80 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Puurunen An α2-adrenergic antagonist, atipamezole, facilitates behavioral recovery after focal cerebral ischemia in rats. Neuropharmacology 2001 PMID: 11249969
- Jurgens α2A adrenergic receptor activation inhibits epileptiform activity in the rat hippocampal CA3 region. Mol.Pharmacol. 2007 PMID: 17341653
- Virtanen Highly selective and specific antagonism of central and peripheral alpha 2-adrenoceptors by atipamezole. Arch.Int.Pharmacodyn.Ther. 1989 PMID: 2567152
Product Specific Notices for Atipamezole hydrochloride
For research use only
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