Medetomidine hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 5160
Potent and highly selective α2 agonist
Key Product Details
Description
Potent and highly selective α2 agonist
Product Description
Medetomidine hydrochloride is a potent, highly selective α2-adrenoceptor agonist (Ki values are 1.08 and 1750 nM for α2- and α1-adrenoceptors respectively). Displays greater selectivity over α1-adrenoceptors than clonidine and UK 14,304 (1620-, 220- and 300-fold respectively). Inhibits twitch response in electrically stimulated mouse vas deferens (pD2 = 9.0). Active in vivo; displays hypotensive, bradycardic, sedative, anxiolytic, hypothermic and analgesic effects.
Active Isomer also available.
Product Specifications
Molecular Weight
236.74
Formula
C13H16N2.HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride
CAS Number
86347-15-1
PubChem ID
68601
InChI Key
VPNGEIHDPSLNMU-UHFFFAOYSA-N
SMILES
CC(C2=CN=CN2)C1=C(C)C(C)=CC=C1.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 23.67 | 100 | |
| DMSO | 23.67 | 100 |
Preparing Stock Solutions
for Medetomidine hydrochloride
The following data is based on the product molecular weight 236.74
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.22 mL | 21.12 mL | 42.24 mL |
| 5 mM | 0.84 mL | 4.22 mL | 8.45 mL |
| 10 mM | 0.42 mL | 2.11 mL | 4.22 mL |
| 50 mM | 0.08 mL | 0.42 mL | 0.84 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Virtanen Characterization of the selectivity, specificity and potency of medetomidine as an α2-adrenoceptor agonist. Eur.J.Pharmacol. 1988 PMID: 2900154
- Scheinin Medetomidine - a novel α2-adrenoceptor agonist: a review of its pharmacodynamic effects. Prog.Neuro-Psychopharm.Biol.Psychiat. 1989 PMID: 2571177
- Savola Evidence for medetomidine as a selective and potent agonist at alpha 2-adrenoceptors. J.Aut.Pharmacol. 1986 PMID: 2880852
Product Specific Notices for Medetomidine hydrochloride
For research use only
Loading...
Loading...