Clonidine hydrochloride

Name: Clonidine hydrochloride
Brand: Tocris Bioscience
SKU: 0690
Rating: 5 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 0690

Citations (9)

(1)

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Key Product Details

Description:	α₂ agonist. Also I₁ ligand
Chemical Name:	2-[(2,6-Dichlorophenyl)amino-2-imidazoline hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	266.56

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Biological Activity for Clonidine hydrochloride

Clonidine hydrochloride is a prototypical I₁ imidazoline receptor ligand. α₂-adrenergic receptor agonist. Antihypertensive. Also thought to enhance autophagy; shown to increase LC3-II levels in PC12 cells.

Technical Data for Clonidine hydrochloride

M. Wt	266.56
Formula	C₉H₉Cl₂N₃.HCl
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	4205-91-8
PubChem ID	20179
InChi Key	ZNIFSRGNXRYGHF-UHFFFAOYSA-N
Smiles	Cl[H].ClC1=CC=CC(Cl)=C1\N=C1/NCCN1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Clonidine hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	26.66	100
	DMSO	13.33	50

Preparing Stock Solutions for Clonidine hydrochloride

The following data is based on the product molecular weight 266.56.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.75 mL	18.76 mL	37.52 mL
5 mM	0.75 mL	3.75 mL	7.50 mL
10 mM	0.38 mL	1.88 mL	3.75 mL
50 mM	0.08 mL	0.38 mL	0.75 mL

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References for Clonidine hydrochloride

References are publications that support the biological activity of the product.

Williams Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. Nat.Chem.Biol. 2008 PMID: 18391949
Armitsu Mechanism of relaxant effect of clon. in isolated bovine tracheal smooth muscle. J.Pharmacol.Exp.Ther. 1998 PMID: 9694921
Silva Dual effect of clon. on mesenteric artery adrenoreceptors: agonistic (alpha-2) and antagonistic (alpha-1). J.Pharmacol.Exp.ther. 1996 PMID: 8627569
Greney Isolation of a human cerebral imidazoline-specific binding protein. Eur.J.Pharmacol. 1994 PMID: 7883019
Ernsberger clon. binds to imidazole binding sites as well as α₂-adrenoceptors in the ventrolateral medulla. Eur.J.Pharmacol. 1987 PMID: 3030779

Citations for Clonidine hydrochloride (9)

Showing 1 - 9 of 9 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Clonidine hydrochloride include:

Harris et al. (2018) Dorsal BNST α2A-Adrenergic Receptors Produce HCN-Dependent Excitatory Actions That Initiate Anxiogenic Behaviors. J Neurosci. 38:8922
PMID: 30150361
Devoto et al. (2015) Selective inhibition of DA-β-hydroxylase enhances DA release from noradrenergic terminals in the medial prefrontal cortex. Mol Pain. 5:e00393
PMID: 26516613
Yuen et al. (2014) Synergistic regulation of glutamatergic transmission by serotonin and NE reuptake inhibitors in prefrontal cortical neurons. J Biol Chem. 289:25177
PMID: 25056951
Cinelli et al. (2013) Suppression of the cough reflex by α 2-adrenergic receptor agonists in the rabbit. Physiol Rep. 1:e00122
PMID: 24400133
Asiedu et al. (2012) Modulation of spinal GABAergic analgesia by inhibition of chloride extrusion capacity in mice. J Pain. 13:546
PMID: 22537560
Liu et al. (2011) Ongoing pain in the MIA model of osteoarthritis. Neurosci Lett. 493:72
PMID: 21241772
Kim et al. (2011) Icilin-evoked behavioral stimulation is attenuated by alpha₂-adrenoceptor activation. Brain Res. 1384:110
PMID: 21315691
Okun et al. (2011) Transient inflammation-induced ongoing pain is driven by TRPV1 sensitive afferents. Purinergic Signal. 7:4
PMID: 21219650
Garzón et al. (2009) Gz mediates the long-lasting desensitization of brain CB1 receptors and is essential for cross-tolerance with mor. Mol Pain. 5:11
PMID: 19284549

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Customer Reviews for Clonidine hydrochloride (1)

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Behavioral pharmacology studies in rodents

Name: Anonymous

Species: Rat

Assay Type: In Vivo

Behavioral pharmacology. Systemic blockade of alpha2- noradrenergic receptors. Dissolved in water at doses of 0.01-1.0 mg/mL and injected systemically in rats. Has sedative effects on motor movement.

High doses (great than 1 mg/kg) results in self-injurious behavior in rats.

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