B-HT 933 dihydrochloride

Name: B-HT 933 dihydrochloride
Brand: Tocris Bioscience
SKU: 2758

Catalog # 2758 | Tocris Bioscience a Bio-Techne Brand

Citations (1)

COA / SDS

Selective α2 agonist

Key Product Details

Description:	Selective α₂ agonist
Alternative Names:	Azepexole
Chemical Name:	6-Ethyl-5,6,7,8-tetrahydro-4H-oxazolo[4,5-d]azepin-2-amine dihydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	254.16

View Full Technical Details for B-HT 933 dihydrochloride

Technical Data
Citations (1) / Reviews

Biological Activity for B-HT 933 dihydrochloride

B-HT 933 dihydrochloride is a selective α2-adrenoceptor agonist. Exhibits greater than 300-fold selectivity for the α2-adrenoceptor over the α1-adrenoceptor.

Compound Libraries for B-HT 933 dihydrochloride

B-HT 933 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for B-HT 933 dihydrochloride

M. Wt	254.16
Formula	C₉H₁₅N₃O.2HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	36067-72-8
PubChem ID	169743
InChi Key	HBLPYIOKPJVFQW-UHFFFAOYSA-N
Smiles	CCN1CCC(OC(N)=N2)=C2CC1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for B-HT 933 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	25.42	100
	DMSO	12.71	50

Preparing Stock Solutions for B-HT 933 dihydrochloride

The following data is based on the product molecular weight 254.16.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.93 mL	19.67 mL	39.35 mL
5 mM	0.79 mL	3.93 mL	7.87 mL
10 mM	0.39 mL	1.97 mL	3.93 mL
50 mM	0.08 mL	0.39 mL	0.79 mL

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Reconstitution Calculator

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References for B-HT 933 dihydrochloride

References are publications that support the biological activity of the product.

Parkinson and Hughes The mechanism of action of α₂-adrenoceptors in human isolated subcutaneous resistance arteries. Br.J.Pharmacol. 1995 PMID: 8564206
Bill The thermogenic actions of α₂-adrenoceptor agonists in reserpinized mice are mediated via a central postsynaptic α₂-adrenoceptor mechanism. Br.J.Pharmacol. 1989 PMID: 2564288
Kobinger and Pichler Pharmacological characterization of B-HT 933 (2-amino-6-ethyl-4,5,7,8-tetrahydro-6H-oxazolo-[5,4-d]-azepindihydrochloride) as a hypotensive agent of the "clonidine-type". Naunyn-Schmied.Arch.Pharmacol. 1977 PMID: 22821

Citations for B-HT 933 dihydrochloride (1)

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Citations are publications that use Bio-Techne products. Selected citations for B-HT 933 dihydrochloride include:

Hamby et al. (2012) Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors. Toxins (Basel). 32:14489
PMID: 23077035

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