SKF 86466 hydrochloride

Name: SKF 86466 hydrochloride
Brand: Tocris Bioscience
SKU: 3866
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3866

(1)

Citations (1)

COA / SDS

Potent and selective α2 antagonist

Key Product Details

Description:	Potent and selective α₂ antagonist
Chemical Name:	6-Chloro-N-methyl-2,3,4,5-tetrahydro-1-H-3-benzazepine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	232.15

View Full Technical Details for SKF 86466 hydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for SKF 86466 hydrochloride

SKF 86466 hydrochloride is a potent and selective α₂ antagonist at pre- and post-junctional α₂-adrenoceptors (K_i values are 13 and 17 nM respectively). Exhibits antihypertensive activity in a rat model.

Compound Libraries for SKF 86466 hydrochloride

SKF 86466 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SKF 86466 hydrochloride

M. Wt	232.15
Formula	C₁₁H₁₄ClN.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	86129-54-6
PubChem ID	10220250
InChi Key	JKQKVNMNAIFCFS-UHFFFAOYSA-N
Smiles	CN2CCC1=CC=CC(Cl)=C1CC2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SKF 86466 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	23.21	100
	DMSO	23.21	100

Preparing Stock Solutions for SKF 86466 hydrochloride

The following data is based on the product molecular weight 232.15.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.31 mL	21.54 mL	43.08 mL
5 mM	0.86 mL	4.31 mL	8.62 mL
10 mM	0.43 mL	2.15 mL	4.31 mL
50 mM	0.09 mL	0.43 mL	0.86 mL

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Reconstitution Calculator

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References for SKF 86466 hydrochloride

References are publications that support the biological activity of the product.

Schafers An evaluation of the alpha-adrenoceptor antagonism produced by SK&F 86466 in healthy normotensive males. Br.J.Clin.Pharmacol. 1990 PMID: 1981137
Hieble Selective alpha-2 adrenoceptor blockade by SK&F 86466: in vitro characterization of receptor sensitivity. J.Pharmacol.Exp.Ther. 1985 PMID: 2867217
Roesler Characterization of the antihypertensive activity of SK&F 86466, a selective alpha-2 antagonist, in the rat. J.Pharmacol.Exp.Ther. 1986 PMID: 2867209