SKF 86466 hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 3866

Potent and selective α2 antagonist
Catalog #
Availability
Size / Price
Qty
3866/10
3866/50
Print Quote
Bulk Order
100% Guarantee

Key Product Details

Description

Potent and selective α2 antagonist

View all Adrenergic alpha-2 Receptor Antagonists »

Product Description

SKF 86466 hydrochloride is a potent and selective α2 antagonist at pre- and post-junctional α2-adrenoceptors (Ki values are 13 and 17 nM respectively). Exhibits antihypertensive activity in a rat model.

Product Specifications

Molecular Weight

232.15

Formula

C11H14ClN.HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

6-Chloro-N-methyl-2,3,4,5-tetrahydro-1-H-3-benzazepine hydrochloride

CAS Number

86129-54-6

PubChem ID

10220250

InChI Key

JKQKVNMNAIFCFS-UHFFFAOYSA-N

SMILES

CN2CCC1=CC=CC(Cl)=C1CC2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 23.21 100
DMSO 23.21 100

Preparing Stock Solutions for SKF 86466 hydrochloride

The following data is based on the product molecular weight 232.15

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.31 mL 21.54 mL 43.08 mL
5 mM 0.86 mL 4.31 mL 8.62 mL
10 mM 0.43 mL 2.15 mL 4.31 mL
50 mM 0.09 mL 0.43 mL 0.86 mL

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

x
=
x

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product.

Product Documents for SKF 86466 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SKF 86466 hydrochloride

For research use only

Privacy Policy
Cookie Policy
Site Map
© Copyright 2026 Bio-Techne. All Rights Reserved. All trademarks and registered trademarks are the property of Bio-Techne and its brands unless otherwise specified.