UK 14,304 tartrate

Name: UK 14,304 tartrate
Brand: Tocris Bioscience
SKU: 2466

Tocris Bioscience, part of Bio-Techne | Catalog # 2466

Citations (15)

COA / SDS

α2 agonist. Water-soluble form of UK 14,304 (Cat. No. 0425)

Key Product Details

Description:	α₂ agonist. Water-soluble form of UK 14,304 (Cat. No. 0425)
Chemical Name:	5-Bromo-6-(2-imidazolin-2-ylamino)quinoxaline tartrate
Purity:	≥98% (HPLC)
Molecular Weight:	442.23

View Full Technical Details for UK 14,304 tartrate

Technical Data
Citations

Biological Activity for UK 14,304 tartrate

UK 14,304 tartrate is a water-soluble form of UK 14,304 (Cat. No. 0425). Full α₂ adrenergic agonist. Centrally active following systemic administration in vivo.

Technical Data for UK 14,304 tartrate

M. Wt	442.23
Formula	C₁₁H₁₀BrN₅.C₄H₆O₆
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	70359-46-5
PubChem ID	11236066
InChi Key	QZHBYNSSDLTCRG-UHFFFAOYSA-N
Smiles	O=C(O)C(O)C(O)C(O)=O.BrC2=C(NC3=NCCN3)C=CC1=NC=CN=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for UK 14,304 tartrate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	22.11	50

Preparing Stock Solutions for UK 14,304 tartrate

The following data is based on the product molecular weight 442.23.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.52 mL	22.61 mL	45.23 mL
2.5 mM	0.90 mL	4.52 mL	9.05 mL
5 mM	0.45 mL	2.26 mL	4.52 mL
25 mM	0.09 mL	0.45 mL	0.90 mL

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References for UK 14,304 tartrate

References are publications that support the biological activity of the product.

Chopin Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxyDA lesions of the nigrostriatal pathway. J.Pharmacol.Exp.Ther. 1999 PMID: 9918591
Andorn Specific [³H]UK-14,304 binding in human cortex occurs at multiple high affinity states with α₂-adrenergic selectivity and different affinities for GTP. Life Sci. 1988 PMID: 2904634
Macdonald Gene targeting - homing in on α₂-adrenoceptor-subtype function. TiPS 1997 PMID: 9227000
Cambridge UK-14,304, a potent and selective alpha2-gonist for the characterisation of alpha-adrenoceptor subtypes. Eur.J.Pharmacol. 1981 PMID: 6115759