RX 821002 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 1324
Potent, selective α2D antagonist
Key Product Details
Description
Potent, selective α2D antagonist
Product Description
RX 821002 hydrochloride is a potent, selective α2-adrenoceptor antagonist with very low affinity for imidazoline sites. Displays selectivity for the α2D over the α2A subtypes (pKd values are 9.7 and 8.2 respectively).Product Specifications
Molecular Weight
270.72
Formula
C12H14N2O3.HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
2-(2,3-Dihydro-2-methoxy-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-imidazole hydrochloride
CAS Number
109544-45-8
PubChem ID
11957683
InChI Key
IMPOOMVZVWKSAP-UHFFFAOYSA-N
SMILES
Cl.COC1(COC2=CC=CC=C2O1)C1=NCCN1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 100 | ||
| DMSO | 27.07 | 100 |
Preparing Stock Solutions
for RX 821002 hydrochloride
The following data is based on the product molecular weight 270.72
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.69 mL | 18.47 mL | 36.94 mL |
| 5 mM | 0.74 mL | 3.69 mL | 7.39 mL |
| 10 mM | 0.37 mL | 1.85 mL | 3.69 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.74 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- O'Rourke Characterisation of [3H]RX 821002 binding to alpha-2 adrenergic receptor subtypes. J.Pharmacol.Exp.Ther. 1994 PMID: 7908054
- Trendelenburg Antagonists that differentiate between α2A- and α2D-adrenoceptors. Naunyn Schmiedebergs Arch.Pharmacol. 1996 PMID: 8692278
- Erdbrugger Does [3H]2-methoxy-idazoxan (RX 821002) detect more alpha-2-adrenoceptor agonist high-affinity sites than [3H]rauwolscine? A comparison of nine tissues and cell lines. J.Pharmacol.Exp.Ther. 1995 PMID: 7791100
Product Specific Notices for RX 821002 hydrochloride
For research use only
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