Tizanidine hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 3609
α2 agonist
Product Description
Tizanidine hydrochloride is an α2-adrenergic receptor agonist. Antinociceptive upon epidural administration in rats (IC50 = 48 nM). Also binds to imidazoline receptor.Product Specifications
Molecular Weight
290.17
Formula
C9H8ClN5S.HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
5-(Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine hydrochloride
CAS Number
64461-82-1
PubChem ID
114869
InChI Key
ZWUKMNZJRDGCTQ-UHFFFAOYSA-N
SMILES
ClC2=C(NC3=NCCN3)C1=NSN=C1C=C2.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 29.02 | 100 | |
| DMSO | 29.02 | 100 |
Preparing Stock Solutions
for Tizanidine hydrochloride
The following data is based on the product molecular weight 290.17
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.45 mL | 17.23 mL | 34.46 mL |
| 5 mM | 0.69 mL | 3.45 mL | 6.89 mL |
| 10 mM | 0.34 mL | 1.72 mL | 3.45 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.69 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Piletz Autoradiographic comparison of [3H]-Clonidine binding to non-adrenergic sites and α2-adrenergic receptors in human brain. Neuropsychopharmacology 2000 PMID: 11063925
- Asano Antinociception by epidural and systemic α2-adrenoceptor agonists and their binding affinity in rat spinal cord and brain. Anesth.Analg. 2000 PMID: 10648329
Product Specific Notices for Tizanidine hydrochloride
For research use only
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