Cultrex™ Extracellular Matrices for 2-D & 3-D Cell Culture

Cultrex is Your Cell Matrix Solution

Cultrex Basement Membrane Extracts (BME) are solubilized extracellular matrices (ECM) purified from the Englebreth-Holm-Swarm (EHS) murine tumor and are rich in extracellular matrix proteins, such as laminin, collagen IV, entactin, and heparan sulfate proteoglycans. Polymerizing at 37 °C, they provide structural support for cells, plus play an important role in establishing tissue organization by influencing cell adhesion, proliferation, migration, and differentiation. Basement membranes are used to promote and maintain a differentiated phenotype in endothelial cells, epithelial cells, smooth muscle cells, glandular cells, and neurons, and are also used for angiogenesis assays, cell invasion assays, neurite outgrowth assays, and in vivo tumorigenicity assays. Multiple different formats of Cultrex Basement Membrane Extract have been qualified for specific 2-D and 3-D cell culture applications. Most formulations are also available with reduced growth factor content and with or without phenol red. Purified extracellular matrix proteins are also available.