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Cultrex Basement Membrane Extract, PathClear
R&D Systems, Inc. a Bio-Techne Brand
Key Product Details
| Features: | Cultrex Basement Membrane Extract (BME) is an extracellular matrix hydrogel that has been used extensively in general cell culture applications to study cell attachment, proliferation, and invasion. |
| Key Benefits: |
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Citations for Cultrex Basement Membrane Extract, PathClear (43)
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Citations are publications that use Bio-Techne products. Selected citations for Cultrex Basement Membrane Extract, PathClear include:
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Species: Mouse
Sample Types: Whole Cells
Applications: BioassayMR Riccetti et al. (2022-01-01), Maladaptive functional changes in alveolar fibroblasts due to perinatal hyperoxia impair epithelial differentiation JCI Insight, 0(0).
PMID: 35113810 -
Species: Rat
Sample Types: Whole Cells
Applications: BioassayRN Power et al. (2022-01-01), Development of a Gene-Activated Scaffold Incorporating Multifunctional Cell-Penetrating Peptides for pSDF-1alpha Delivery for Enhanced Angiogenesis in Tissue Engineering Applications International Journal of Molecular Sciences, 23(3).
PMID: 35163379 -
Species: Rat
Sample Types: Whole Cell
Applications: Cell CultureMM Schwarz et al. (2022-01-01), Oropouche orthobunyavirus infection is mediated by the cellular host factor Lrp1 Proceedings of the National Academy of Sciences of the United States of America, 119(33):e2204706119.
PMID: 35939689 -
Species: Human
Sample Types: Organoid
Applications: BioassayEI Rivas et al. (2022-01-01), Targeted immunotherapy against distinct cancer-associated fibroblasts overcomes treatment resistance in refractory HER2+ breast tumors Nature Communications, 13(1):5310.
PMID: 36085201 -
Species: Human
Sample Types: Organoid
Applications: BioassayW Yu et al. (2022-01-01), YAP 5-methylcytosine modification increases its mRNA stability and promotes the transcription of exosome secretion-related genes in lung adenocarcinoma Cancer Gene Therapy, 0(0).
PMID: 36123390 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayH Chen et al. (2022-01-01), Extracellular vesicles-transferred SBSN drives glioma aggressiveness by activating NF-kappaB via ANXA1-dependent ubiquitination of NEMO Oncogene, 0(0).
PMID: 36316443 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayPK Yang et al. (2021-01-01), Obesity alters ovarian folliculogenesis through disrupted angiogenesis from increased IL-10 production Molecular Metabolism, 49(0):101189.
PMID: 33592337 -
Species: Trypanosoma brucei
Sample Types: Whole Cells
F Rojas et al. (2021-01-01), Basement membrane proteins as a substrate for efficient Trypanosoma brucei differentiation in vitro PloS Neglected Tropical Diseases, 15(4):e0009284.
PMID: 33909626 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayF Keller et al. (2021-01-01), Extracellular Matrix Components Regulate Bone Sialoprotein Expression in MDA-MB-231 Breast Cancer Cells Cells, 10(6).
PMID: 34073955 -
MS Hansen et al. (2020-01-01), Specific and Non-Invasive Fluorescent Labelling of Extracellular Vesicles for Evaluation of Intracellular Processing by Intestinal Epithelial Cells Biomedicines, 8(7).
PMID: 32674302 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayJ Finlay-Sch et al. (2020-01-01), New generation breast cancer cell lines developed from patient-derived xenografts Breast Cancer Res., 22(1):68.
PMID: 32576280 -
Species: Mouse
Sample Types: Whole Cells
BL Baechler et al. (2019-01-01), Mitophagy regulates mitochondrial network signaling, oxidative stress, and apoptosis during myoblast differentiation Autophagy, 0(0).
PMID: 30859901 -
Species: Mouse
Sample Types: Protein
Applications: OxidationT Nybo et al. (2019-01-01), Analysis of protein chlorination by mass spectrometry Redox Biol, 26(0):101236.
PMID: 31181457 -
(2016-01-01), Transposon mutagenesis identifies genes that cooperate with mutant Pten in breast cancer progression Proc. Natl. Acad. Sci. U.S.A., 0(0).
PMID: 27849608 -
(2016-01-01), Wnt signaling promotes breast cancer by blocking ITCH-mediated degradation of the YAP/TAZ transcriptional coactivator WBP2 Cancer Res, 0(0).
PMID: 27578003 -
Sameni M et al. (2015-01-01), Cabozantinib (XL184) Inhibits Growth and Invasion of Preclinical TNBC Models. Clin Cancer Res, 22(4):923-34.
PMID: 26432786 -
Caccuri et al. (2014-01-01), Simian immunodeficiency virus and human immunodeficiency virus type 1 matrix proteins specify different capabilities to modulate B cell growth. J Virol, 88(10):5706-17.
PMID: 24623414 -
Bittencourt F et al. (2014-01-01), The M33 G protein-coupled receptor encoded by murine cytomegalovirus is dispensable for hematogenous dissemination but is required for growth within the salivary gland. J Virol, 88(20):11811-24.
PMID: 25100846 -
Zhu B et al. (), The nuclear receptor peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) promotes oncogene-induced cellular senescence through repression of endoplasmic reticulum stress. J Biol Che289(29):20102-19.
PMID: 24898257 -
Messer W et al. (), Timing and targeting: the biological functions of Dam methylation in E. coli. Cel54(6):735-7.
PMID: 2842065 -
Traini S et al. (), Inhibition of tumor growth and angiogenesis by SP-2, an anti-lectin, galactoside-binding soluble 3 binding protein (LGALS3BP) antibody. Mol Cancer The13(4):916-25.
PMID: 24552775 -
Krausz E et al. (), Translation of a tumor microenvironment mimicking 3D tumor growth co-culture assay platform to high-content screening. J Biomol Scree18(1):54-66.
PMID: 22923784 -
Hsu I et al. (), Suppression of ERbeta signaling via ERbeta knockout or antagonist protects against bladder cancer development. Carcinogenesi35(3):651-61.
PMID: 24148819 -
Zhang W et al. (), Microfluidics separation reveals the stem-cell-like deformability of tumor-initiating cells. Proc Natl Acad Sci U S 109(46):18707-12.
PMID: 23112172 -
Jones B et al. (), Dual Targeting of Mesenchymal and Amoeboid Motility Hinders Metastatic Behavior. Mol Cancer Re15(6):670-682.
PMID: 28235899 -
Stadem P et al. (), Markers of oxidative stress in umbilical cord blood from G6PD deficient African newborns. PLoS ON12(2):e0172980.
PMID: 28235023 -
Willuda J et al. (), Preclinical Antitumor Efficacy of BAY 1129980-a Novel Auristatin-Based Anti-C4.4A (LYPD3) Antibody-Drug Conjugate for the Treatment of Non-Small Cell Lung Cancer. Mol Cancer The16(5):893-904.
PMID: 28292941 -
Crispel Y et al. (), Involvement of the heparanase procoagulant domain in bleeding and wound healing. J Thromb Haemos15(7):1463-1472.
PMID: 28439967 -
Ogawa R et al. (), Mouse embryonic dorsal root ganglia contain pluripotent stem cells that show features similar to embryonic stem cells and induced pluripotent stem cells. Biol Ope6(5):602-618.
PMID: 28373172 -
Spinella F et al. (), The interplay between hypoxia, endothelial and melanoma cells regulates vascularization and cell motility through endothelin-1 and vascular endothelial growth factor. Carcinogenesi35(4):840-8.
PMID: 24473118 -
Withana N et al. (), Cathepsin B inhibition limits bone metastasis in breast cancer. Cancer Re72(5):1199-209.
PMID: 22266111 -
Jaykumar A et al. (), Real-time monitoring of NKCC2 endocytosis by total internal reflection fluorescence (TIRF) microscopy. Am J Physiol Renal Physio310(2):F183-91.
PMID: 26538436 -
Binda E et al. (), Wnt5a Drives an Invasive Phenotype in Human Glioblastoma Stem-like Cells. Cancer Re77(4):996-1007.
PMID: 28011620 -
Caccuri F et al. (), HIV-1 matrix protein p17 promotes angiogenesis via chemokine receptors CXCR1 and CXCR2. Proc Natl Acad Sci U S 109(36):14580-5.
PMID: 22904195 -
Kolev V et al. (), PI3K/mTOR dual inhibitor VS-5584 preferentially targets cancer stem cells. Cancer Re75(2):446-55.
PMID: 25432176 -
Clocchiatti A et al. (), The MEF2-HDAC axis controls proliferation of mammary epithelial cells and acini formation in vitro. J Cell Sc128(21):3961-76.
PMID: 26403201 -
Beke L et al. (), MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells. Biosci Re35(6).
PMID: 26431963 -
Cieply B et al. (), Suppression of the epithelial-mesenchymal transition by Grainyhead-like-2. Cancer Re72(9):2440-53.
PMID: 22379025 -
Zhang W et al. (), A humanized single-chain antibody against beta 3 integrin inhibits pulmonary metastasis by preferentially fragmenting activated platelets in the tumor microenvironment. Bloo120(14):2889-98.
PMID: 22879538 -
Sen M et al. (), p16 controls epithelial cell growth and suppresses carcinogenesis through mechanisms that do not require RB1 function. Oncogenesi6(4):e320.
PMID: 28414317 -
Munson J et al. (), Anti-invasive adjuvant therapy with imipramine blue enhances chemotherapeutic efficacy against glioma. Sci Transl Me4(127):127ra36.
PMID: 22461640 -
Kim S et al. (), Regulation of P21-activated kinase-4 by progesterone and tumor necrosis factor-alpha in human endometrium and its increased expression in advanced-stage endometriosis. J Clin Endocrinol Meta98(2):E238-48.
PMID: 23293332 -
Romero D et al. (), Dickkopf-3 regulates prostate epithelial cell acinar morphogenesis and prostate cancer cell invasion by limiting TGF-beta-dependent activation of matrix metalloproteases. Carcinogenesi37(1):18-29.
PMID: 26503968
There are no citations that match your criteria.
Customer Reviews for Cultrex Basement Membrane Extract, PathClear (8)
4.9 out of 5
8 customer ratings
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Verified Customer | Posted 05/25/2023
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Verified Customer | Posted 05/15/2023
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Verified Customer | Posted 11/06/2022
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Verified Customer | Posted 05/23/2022Used for 3D culture experiments. Went very well
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Verified Customer | Posted 02/01/2022for 3D cell culture
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Application: In vivo studyVerified Customer | Posted 08/20/2018
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Application: Cell migration/motilityVerified Customer | Posted 04/01/2018
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Application: Cell ProliferationVerified Customer | Posted 04/01/2018
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FAQs for Cultrex Basement Membrane Extract, PathClear
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What kinds of tumor cells or biopsy specimens grow in vivo with Cultrex® BME?
Many cell lines and tumor biopsy specimens (usually cut into small fragments) have been found to grow in vivo when implanted with Cultrex® BME. These include melanoma, intestinal, prostate, breast, lung, renal, and liver cancers as well as the 3T3 mouse embryonic fibroblast cell line.
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How does Cultrex® Basement Membrane Extract (BME) promote cell differentiation?
All epithelial and endothelial cells are in contact with a basement membrane matrix on at least one of their surfaces. By providing them with their natural matrix in vitro as a substrate for the cells that provides biological cues, the cells can assume a more physiological morphology (i.e. correct shape) and begin expression of cell-lineage specific proteins. Two-dimensional plastic surfaces, in combination with serum-containing media, cause cells to flatten, proliferate and de-differentiate.
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How should Cultrex Basement Membrane Extract (BME) be stored and handled?
Cultrex BME should be stored at or below -20°C for optimal stability. Preparation of working aliquots is recommended. Cultrex BME should be thawed overnight on ice at 4°C, however long term storage at 4°C is not recommended. Freeze/thaw cycles and gel-liquid phase transitions should be avoided, since they can compromise product integrity.
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What is the percent of Laminin I in Cultrex® Basement Membrane Extract, PathClear, Catalog # 3432-010-01?
Cultrex® Basement Membrane Extract (BME), Pathclear, is composed of ≤ 60 % of Laminin I. Laminin is the major component of Cultrex BME. Other components are Collagen IV, which makes up ≤ 40% and Entactin which makes up ≤ 10%.
