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Cultrex Basement Membrane Extract, Type 2, Pathclear
Catalog # 3532-010-02
Key Product Details
| Features: | Cultrex Basement Membrane Extract (BME), Type 2 is specifically designed to support the establishment and expansion of robust organoid cultures. It's composition mimics the in vivo microenvironment to improve take rate and growth of organoid progenitor cells. |
| Key Benefits: |
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Bio-Techne Corporation
tel: (612) 379-2956
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$35 to United States
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Citations for Cultrex Basement Membrane Extract, Type 2, Pathclear (11)
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Citations are publications that use Bio-Techne products. Selected citations for Cultrex Basement Membrane Extract, Type 2, Pathclear include:
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Species: Chicken
Sample Types: Whole Cells
Applications: BioassayZWM Tong et al. (2021), Primary Chicken and Duck Endothelial Cells Display a Differential Response to Infection with Highly Pathogenic Avian Influenza Virus Genes, 12(6).
PMID: 34200798 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayMP Clark et al. (2021), Clinical stage drugs targeting inhibitor of apoptosis proteins purge episomal Hepatitis B viral genome in preclinical models Cell Death Disease, 2021;12(7):641.
PMID: 34162831 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayJ Kulsuptrak et al. (2021), A genome-wide CRISPR screen identifies UFMylation and TRAMP-like complexes as host factors required for hepatitis A virus infection Cell Reports, 34(11):108859.
PMID: 33730579 -
Species: Human
Sample Types: Organoid
X Jin et al. (2020), LncRNA TROJAN promotes proliferation and resistance to CDK4/6 inhibitor via CDK2 transcriptional activation in ER+ breast cancer Mol. Cancer, 19(1):87.
PMID: 32393270 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayX Li et al. (2020), Breast cancer organoids from a patient with giant papillary carcinoma as a high-fidelity model Cancer Cell Int., 20(0):86.
PMID: 32206037 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayKD Hulme et al. (2020), High glucose levels increase influenza-associated damage to the pulmonary epithelial-endothelial barrier Elife, 9(0).
PMID: 32697191 -
Species: Human
Sample Types: Organoids
Applications: BioassayB Pan et al. (2020), Establishment and characterization of breast cancer organoids from a patient with mammary Paget's disease Cancer Cell Int., 20(0):365.
PMID: 32774159 -
Species: Mouse
Sample Types: Organoids
Applications: BioassayP Francica et al. (2020), Functional Radiogenetic Profiling Implicates ERCC6L2 in Non-homologous End Joining Cell Rep, 32(8):108068.
PMID: 32846126 -
Species: Mouse
Sample Types: Organoids
M Barazas et al. (2019), Radiosensitivity Is an Acquired Vulnerability of PARPi-Resistant BRCA1-Deficient Tumors Cancer Res., 79(3):452-460.
PMID: 30530501 -
Klueh U et al. (0), Basement Membrane-Based Glucose Sensor Coatings Enhance Continuous Glucose Monitoring in Vivo. J Diabetes Sci Techno9(5):957-65.
PMID: 26306494 -
Okere B et al. (0), In vitro differentiation of human amniotic epithelial cells into insulin-producing 3D spheroids. Int J Immunopathol Pharmaco28(3):390-402.
PMID: 26216908
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FAQs
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What kinds of tumor cells or biopsy specimens grow in vivo with Cultrex® BME?
Many cell lines and tumor biopsy specimens (usually cut into small fragments) have been found to grow in vivo when implanted with Cultrex® BME. These include melanoma, intestinal, prostate, breast, lung, renal, and liver cancers as well as the 3T3 mouse embryonic fibroblast cell line.
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How does Cultrex® Basement Membrane Extract (BME) promote cell differentiation?
All epithelial and endothelial cells are in contact with a basement membrane matrix on at least one of their surfaces. By providing them with their natural matrix in vitro as a substrate for the cells that provides biological cues, the cells can assume a more physiological morphology (i.e. correct shape) and begin expression of cell-lineage specific proteins. Two-dimensional plastic surfaces, in combination with serum-containing media, cause cells to flatten, proliferate and de-differentiate.
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How should Cultrex Basement Membrane Extract (BME) be stored and handled?
Cultrex BME should be stored at or below -20°C for optimal stability. Preparation of working aliquots is recommended. Cultrex BME should be thawed overnight on ice at 4°C, however long term storage at 4°C is not recommended. Freeze/thaw cycles and gel-liquid phase transitions should be avoided, since they can compromise product integrity.
