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Cultrex Stem Cell Qualified Reduced Growth Factor Basement Membrane Extract

Basement membrane extract specifically qualified to support feeder-free embryonic and pluripotent stem cell culture.

Key Product Details

Features: Cultrex Stem Cell Qualified Reduced Growth Factor Basement Membrane Extract (RGF BME) has been shown to provide an effective feeder-free surface for the attachment and maintenance of human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) in culture.
Key Benefits:
  • Qualified to support the culture of pluripotent stem cell
  • Supports human iPSC and ESC expansion and differentiation
  • Reduced growth factor formulation provides a more defined culture system
  • Quality controlled for performance consistency
Cultrex BME Improves Hematopoietic Stem Cell Differentiation from Induced Pluripotent Stem Cells (iPSCs).
(3)
Colonies of Human iPSCs Grown on Cultrex Stem Cell Qualified RGF BME.
Cultrex Stem Cell Qualified RGF Basement Membrane Extract
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3434-001-02
3434-010-02
3434-005-02

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FAQs

  • What kinds of tumor cells or biopsy specimens grow in vivo with Cultrex® BME?

    Many cell lines and tumor biopsy specimens (usually cut into small fragments) have been found to grow in vivo when implanted with Cultrex® BME. These include melanoma, intestinal, prostate, breast, lung, renal, and liver cancers as well as the 3T3 mouse embryonic fibroblast cell line.

  • How does Cultrex® Basement Membrane Extract (BME) promote cell differentiation?

    All epithelial and endothelial cells are in contact with a basement membrane matrix on at least one of their surfaces. By providing them with their natural matrix in vitro as a substrate for the cells that provides biological cues, the cells can assume a more physiological morphology (i.e. correct shape) and begin expression of cell-lineage specific proteins. Two-dimensional plastic surfaces, in combination with serum-containing media, cause cells to flatten, proliferate and de-differentiate.

  • How should Cultrex Basement Membrane Extract (BME) be stored and handled?

    Cultrex BME should be stored at or below -20°C for optimal stability. Preparation of working aliquots is recommended. Cultrex BME should be thawed overnight on ice at 4°C, however long term storage at 4°C is not recommended. Freeze/thaw cycles and gel-liquid phase transitions should be avoided, since they can compromise product integrity.

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