Voltage-gated Potassium Channel Blockers

DPO-1

Catalog #: 2533

(1)

Citations (26)

Product Documents

Images (1)

Blocker of KV1.5 channel and IKur current

Alternate Names:

Diphenyl phosphine oxide-1

Chemical Name:

[1S-(1α,2α,5β)]-[5-Methyl-2-(1-methylethyl)cyclohexyl]diphenylphosphine oxide

Purity:

≥98%

Linopirdine dihydrochloride

Catalog #: 1999

(1)

Citations (266)

Product Documents

Images (1)

KV7 (KCNQ) channel blocker

Alternate Names:

DuP 996

Chemical Name:

1,3-Dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-2H-indol-2-one dihydrochloride

Purity:

≥98%

BAPTA AM

Catalog #: 2787

(1)

Citations (212)

Product Documents

Images (1)

Cell-permeable Ca2+ chelator

Chemical Name:

1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid tetrakis(acetoxymethyl ester)

Purity:

≥95%

4-Aminopyridine

Catalog #: 0940

(2)

Citations (299)

Product Documents

Images (1)

Non-selective KV channel blocker

Alternate Names:

4-AP

Purity:

≥98%

KN 93

Catalog #: 1278

(1)

Citations (174)

Product Documents

Images (1)

CaM kinase II inhibitor; also K+ channel blocker (KV)

Chemical Name:

N-[2-[[[3-(4-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulphonamide

Purity:

≥98%

E-4031 dihydrochloride

Catalog #: 1808

(2)

Citations (25)

Product Documents

Images (1)

KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)

Chemical Name:

N-[4-[[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide dihydrochloride

Purity:

≥98%

Terfenadine

Catalog #: 3948

(1)

Citations (16)

Product Documents

Images (1)

H1 antagonist. Also KV11.1 (hERG) and Kir6 (KATP) channel blocker

Chemical Name:

α-[4-(1,1-Dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinebutanol

Purity:

≥98%

Guangxitoxin 1E

Catalog #: 5676

(1)

Citations (7)

Product Documents

Images (1)

Potent Kv2.1 and Kv2.2 channel blocker

Purity:

≥95%

Chromanol 293B

Catalog #: 1412

(1)

Citations (49)

Product Documents

Images (1)

IKs blocker. Also blocks ICFTR

Chemical Name:

trans-N-[6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methyl-ethanesulfonamide

Purity:

≥98%

(-)-[3R,4S]-Chromanol 293B

Catalog #: 1475

Citations (6)

Product Documents

Images (1)

IKs blocker. Enantiomer of Chromanol 293B (Cat. No. 1412)

Chemical Name:

N-[(3R,4S)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methylethanesulfonamide

Purity:

≥98%

XE 991 dihydrochloride

Catalog #: 2000

(1)

Citations (1216)

Product Documents

Images (1)

Potent, selective KV7 (KCNQ) channel blocker; blocks M-currents

Chemical Name:

10,10-bis(4-Pyridinylmethyl)-9(10H)-anthracenone dihydrochloride

Purity:

≥98%

UK 78282 hydrochloride

Catalog #: 3829

(1)

Citations (1)

Product Documents

Images (1)

Blocker of KV1.3 and KV1.4 channels

Chemical Name:

4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidine hydrochloride

Purity:

≥98%

Dofetilide

Catalog #: 3757

(1)

Citations (17)

Product Documents

Images (1)

KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)

Alternate Names:

Tikosyn,UK 68798

Chemical Name:

1-(4-Methanesulphonamidophenoxy)-2-[N-(4-methanesulphonamidophenethyl)-N-methylamino]ethane

Purity:

≥98%

Roxadustat

Catalog #: 7486

Citations (4)

Product Documents

Images (1)

HIF-PH inhibitor; erythropoietic

Alternate Names:

FG 4592

Chemical Name:

N-[(4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]glycine

Purity:

≥98%

Astemizole

Catalog #: 3489

(1)

Citations (13)

Product Documents

Images (1)

Orally active, potent H1 antagonist; also KV11.1 (hERG) channel blocker

Alternate Names:

Hismanal

Chemical Name:

1-[(4-Fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]-1H-benzimidazol-2-amine

Purity:

≥98%

JNJ 303

Catalog #: 3899

Citations (22)

Product Documents

Images (1)

Potent and selective IKs blocker

Chemical Name:

2-(4-Chlorophenoxy)-2-methyl-N-[5-[(methylsulfonyl)amino]tricyclo[3.3.1.13,7]dec-2-yl]-propanamide

Purity:

≥98%

KN 92

Catalog #: 4130

(1)

Citations (40)

Product Documents

Images (1)

Inactive analog of KN 93. K+ channel (Kv) blocker

Chemical Name:

2-[N-(4'-Methoxybenzenesulfonyl)]amino-N-(4'-chlorophenyl)-2-propenyl-N-methylbenzylamine phosphate

Purity:

≥98%

Psora 4

Catalog #: 4367

(1)

Citations (5)

Product Documents

Images (1)

Potent KV1.3 channel blocker

Chemical Name:

4-(4-Phenylbutoxy)-7H-furo[3,2-g][1]benzopyran-7-one

Purity:

≥98%

HMR 1556

Catalog #: 5011

(1)

Citations (32)

Product Documents

Images (1)

Potent and selective Iks channel blocker

Chemical Name:

N-[(3R,4S)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-2H-1-benzopyran-4-yl]-N-methylmetanesulfonamide

Purity:

≥98%

ML 252

Catalog #: 4687

Product Documents

Images (1)

Potent and selective KV7.2 inhibitor; brain penetrant

Chemical Name:

(S)-2-Phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide

Purity:

≥98%

Azimilide dihydrochloride

Catalog #: 6318

(1)

Citations (1)

Product Documents

Images (1)

Kv11.1 (hERG) channel blocker

Chemical Name:

1-[[[5-(4-Chlorophenyl)-2-furanyl]methylene]amino]-3-[4-(4-methyl-1-piperazinyl)butyl]-2,4-imidazolidinedione dihydrochloride

Purity:

≥97%

Voltage-gated Potassium Channel Blockers

DPO-1

Linopirdine dihydrochloride

BAPTA AM

4-Aminopyridine

KN 93

E-4031 dihydrochloride

Terfenadine

Guangxitoxin 1E

Chromanol 293B

(-)-[3R,4S]-Chromanol 293B

XE 991 dihydrochloride

UK 78282 hydrochloride

Dofetilide

Roxadustat

Astemizole

JNJ 303

KN 92

Psora 4

HMR 1556

ML 252

Azimilide dihydrochloride

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