Chromanol 293B

Name: Chromanol 293B
Brand: Tocris Bioscience
SKU: 1412
Rating: 5 (1 reviews)

Catalog # 1412 | Tocris Bioscience a Bio-Techne Brand

(1)

Citations (5)

COA / SDS

IKs blocker. Also blocks ICFTR

Key Product Details

Description:	I_Ks blocker. Also blocks I_CFTR
Chemical Name:	trans-N-[6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methyl-ethanesulfonamide
Purity:	≥99% (HPLC)
Molecular Weight:	324.39

View Full Technical Details for Chromanol 293B

Technical Data
Citations (5) / Reviews (1)

Biological Activity for Chromanol 293B

Chromanol 293B is a blocker of the slow delayed rectifier K⁺ current (I_Ks) (IC₅₀ = 1-10 μM). Also blocks the CFTR chloride current (I_CFTR) (IC₅₀ = 19 μM).

Enantiomer also available.

Compound Libraries for Chromanol 293B

Chromanol 293B is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Chromanol 293B

M. Wt	324.39
Formula	C₁₅H₂₀N₂O₄S
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	163163-23-3
PubChem ID	121846
InChi Key	HVSJHHXUORMCGK-UONOGXRCSA-N
Smiles	O[C@H]1[C@H](N(C)S(=O)(CC)=O)C2=C(C=CC(C#N)=C2)OC(C)1C.O[C@@H]3[C@@H](N(C)S(=O)(CC)=O)C4=C(C=CC(C#N)=C4)OC(C)3C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Chromanol 293B

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	6.49	20
	DMSO	32.44	100

Preparing Stock Solutions for Chromanol 293B

The following data is based on the product molecular weight 324.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.08 mL	15.41 mL	30.83 mL
5 mM	0.62 mL	3.08 mL	6.17 mL
10 mM	0.31 mL	1.54 mL	3.08 mL
50 mM	0.06 mL	0.31 mL	0.62 mL

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Reconstitution Calculator

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References for Chromanol 293B

References are publications that support the biological activity of the product.

Bachmann Chromanol 293B, a blocker of the slow delayed rectifier K⁺ current (I_KS), inhibits the CFTR Cl^- current. Naunyn Schmiedebergs Arch.Pharmacol. 2001 PMID: 11414653
Sun Chromanol 293B inhibits slowly activating delayed rectifier and transient outward currents in canine left ventricular myocytes. J.Cardiovasc.Electrophysiol. 2001 PMID: 11332571
Fujisawa Time-dependent block of the slowly activating delayed rectifier K⁺ current by chromanol 293B in guinea-pig ventricular cells. Br.J.Pharmacol. 2000 PMID: 10696102

Citations for Chromanol 293B (5)

Showing 1 - 5 of 5 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Chromanol 293B include:

Inagaki et al. (2019) Involvement of butyrate in electrogenic K+ secretion in rat rectal colon. Pflugers Arch. 471:313
PMID: 30250967
Yu et al. (2014) Apamin does not inhibit human cardiac Na+ current, L-type Ca2+ current or other major K+ currents. J Cell Mol Med. 9:e96691
PMID: 24798465
McCallum et al. (2011) The contribution of Kv7 channels to pregnant mouse and human myometrial contractility. Mol Pain. 15:577
PMID: 20132415
Neal et al. (2011) Renal defects in KCNE1 knockout mice are mimicked by chromanol 293B in vivo: identification of a KCNE1-regulated K+ conductance in the proximal tubule. J Physiol. 589:3595
PMID: 21576273
Gage and Kobertz (2004) KCNE3 truncation mutants reveal a bipartite modulation of KCNQ1 K+ channels. J Gen Physiol. 124:759
PMID: 15572349

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Customer Reviews for Chromanol 293B (1)

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Chromanol 293B was used to assess how it regulates the gating kinetics of Kv2.1

Name: Anonymous

Species: Human

Assay Type: In Vitro

Chromanol 293B was used to assess how it regulates the gating kinetics of Kv2.1. The blocking action exhibited by the product was measured on epithelial Kv2.1 channels.

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