UK 78282 hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 3829

Blocker of KV1.3 and KV1.4 channels
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Key Product Details

Description

Blocker of KV1.3 and KV1.4 channels

View all Voltage-gated Potassium Channel Blockers »

Product Description

UK 78282 hydrochloride is a blocker of the KV1.3 and KV1.4 voltage-gated potassium channels in T lymphocytes (IC50 values are 0.28 and 0.17 μM respectively). Suppresses T lymphocyte mitogenesis; leads to membrane depolarization. Also blocks KV1.4 expressed in heart and brain.

Product Specifications

Molecular Weight

466.05

Formula

C29H35NO2.HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidine hydrochloride

CAS Number

136647-02-4

PubChem ID

53393337

InChI Key

ZZSQARULZYQMIG-UHFFFAOYSA-N

SMILES

COC(C=C3)=CC=C3CCCN1CCC(COC(C4=CC=CC=C4)C2=CC=CC=C2)CC1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.3 50
Ethanol 13.98 30

Preparing Stock Solutions for UK 78282 hydrochloride

The following data is based on the product molecular weight 466.05

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.29 mL 21.46 mL 42.91 mL
2.5 mM 0.86 mL 4.29 mL 8.58 mL
5 mM 0.43 mL 2.15 mL 4.29 mL
25 mM 0.09 mL 0.43 mL 0.86 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for UK 78282 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for UK 78282 hydrochloride

For research use only

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