JNJ 303
Tocris Bioscience, part of Bio-Techne | Catalog # 3899
Potent and selective IKs blocker
Key Product Details
Description
Potent and selective IKs blocker
Product Description
JNJ 303 is a potent IKs blocker (IC50 = 64 nM). Displays no effects on other cardiac channels; IC50 values are 3.3, >10, 11.1 and 12.6 μM for INa, ICa, Ito and IKr currents respectively. Prolongs QT and causes unprovoked torsades de pointes (TdP).Licensing Information
Sold with the permission of Janssen Pharmaceutica NVProduct Specifications
Molecular Weight
440.98
Formula
C21H29ClN2O4S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
2-(4-Chlorophenoxy)-2-methyl-N-[5-[(methylsulfonyl)amino]tricyclo[3.3.1.13,7]dec-2-yl]-propanamide
CAS Number
878489-28-2
PubChem ID
73016713
InChI Key
OSGIRCJRKSAODN-UHFFFAOYSA-N
SMILES
O=C(C(C)(C)OC4=CC=C(Cl)C=C4)NC2C1CC(CC2C3)CC3(NS(=O)(C)=O)C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 11.02 | 25 |
Preparing Stock Solutions
for JNJ 303
The following data is based on the product molecular weight 440.98
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 9.07 mL | 45.35 mL | 90.71 mL |
| 1.25 mM | 1.81 mL | 9.07 mL | 18.14 mL |
| 2.5 mM | 0.91 mL | 4.54 mL | 9.07 mL |
| 12.5 mM | 0.18 mL | 0.91 mL | 1.81 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Towart Blockade of the IKs potassium channel: an overlooked cardiovascular liability in drug safety screening? J.Pharm.Toxicol.Meth
Product Specific Notices for JNJ 303
For research use only
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