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Key Product Details
| Description: | Non-selective KV channel blocker |
| Alternative Names: | 4-AP |
| Purity: | ≥99% (HPLC) |
Complete Your Research
Showing 1-5 of 32 citations
Citations (32)
Citations are publications that use Bio-techne products. Selected citations for 4-Aminopyridine include:
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Gutzmann et al.
(2019)
Functional Coupling of Cav2.3 and BK Potassium Channels Regulates Action Potential Repolarization and Short-Term Plasticity in the Mouse Hippocampus.
Front Cell Neurosci.
13:27
PMID: 30846929 -
Chiu et al.
(2019)
NMDAR-Activated PP1 Dephosphorylates GluN2B to Modulate NMDAR Synaptic Content.
Cell Rep.
28:332
PMID: 31291571 -
Collins et al.
(2018)
Reciprocal Circuits Linking the Prefrontal Cortex with Dorsal and Ventral Thalamic Nuclei.
Neuron.
98:366
PMID: 29628187 -
Beas et al.
(2018)
The locus coeruleus drives disinhibition in the midline thalamus via a dopaminergic mechanism.
Nat Neurosci.
21:963
PMID: 29915192 -
Chang and Higley
(2018)
Potassium channels contribute to activity-dependent regulation of dendritic inhibition.
Physiol Rep.
6:e13747
PMID: 29939492 -
Fan et al.
(2018)
All-optical synaptic electrophysiology probes mechanism of ketamine-induced disinhibition.
Nat Methods.
15:823
PMID: 30275587 -
Li et al.
(2018)
Hypothalamic Circuits for Predation and Evasion.
Neuron.
97:911
PMID: 29398361 -
Dong et al.
(2018)
CAST/ELKS Proteins Control Voltage-Gated Ca2+ Channel Density and Synaptic Release Probability at a Mammalian Central Synapse.
Cell Rep.
24:284
PMID: 29996090 -
Zhang et al.
(2018)
Pauses in Cholinergic Interneuron Activity Are Driven by Excitatory Input and Delayed Rectification, with DA Modulation.
Neuron.
98:918
PMID: 29754751 -
Kiritoshi and Neugebauer
(2018)
Pathway-specific alterations of cortico-amygdala transmission in an arthritis pain model.
ACS Chem Neurosci.
9:2252
PMID: 29630339 -
Zhao et al.
(2017)
A Central Catecholaminergic Circuit Controls Blood Glucose Levels during Stress.
Neuron.
95:138
PMID: 28625488 -
Dinamarca et al.
(2016)
Ring finger protein 10 is a novel synaptonuclear messenger encoding activation of NMDA receptors in hippocampus.
Elife.
5
PMID: 26977767 -
Cramer et al.
(2015)
Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse.
Front Cell Neurosci.
35:5664
PMID: 25855180 -
Robinson et al.
(2015)
Tissue plasminogen activator inhibits NMDA-receptor-mediated increases in calcium levels in cultured hippocampal neurons.
J Neurosci.
9:404
PMID: 26500501 -
Curcio et al.
(2015)
Brain ischemia downregulates the neuroprotective GDNF-Ret signaling by a calpain-dependent mechanism in cultured hippocampal neurons.
J Neurosci.
6:e1645
PMID: 25675305 -
Saunders et al.
(2015)
Corelease of acetylcholine and GABA from cholinergic forebrain neurons.
Front Neural Circuits.
4
PMID: 25723967 -
Grace et al.
(2014)
Identification of a pharmacological target for genioglossus reactivation throughout sleep.
Elife.
37:41
PMID: 24470694 -
Leal et al.
(2014)
Neuronal activity induces synaptic delivery of hnRNP A2/B1 by a BDNF-dependent mechanism in cultured hippocampal neurons.
PLoS One.
9:e108175
PMID: 25286195 -
Chanda et al.
(2014)
Generation of induced neuronal cells by the single reprogramming factor ASCL1.
J Neurosci.
3:282
PMID: 25254342 -
Chanda et al.
(2013)
Neurons generated by direct conversion of fibroblasts reproduce synaptic phenotype caused by autism-associated neuroligin-3 mutation.
J Biol Chem.
110:16622
PMID: 24046374 -
Gaamouch et al.
(2012)
Interaction between αCaMKII and GluN2B controls ERK-dependent plasticity.
J Neurosci.
32:10767
PMID: 22855824 -
Hagiwara et al.
(2012)
Optophysiological analysis of associational circuits in the olfactory cortex.
Cell Death Dis.
6:18
PMID: 22529781 -
Kaufman et al.
(2012)
Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons.
Sleep.
32:3992
PMID: 22442066 -
Saliba et al.
(2012)
Activity-dependent phosphorylation of GABAA receptors regulates receptor insertion and tonic current.
J Neurophysiol.
31:2937
PMID: 22531784 -
Shulga et al.
(2012)
The loop diuretic bumet. blocks posttraumatic p75NTR upregulation and rescues injured neurons.
J Neurosci.
32:1757
PMID: 22302815 -
Restituito et al.
(2011)
Synaptic autoregulation by metalloproteases and γ-secretase.
J Neurosci.
31:12083
PMID: 21865451 -
Fontán-Lozano et al.
(2011)
The A-current modulates learning via NMDA receptors containing the NR2B subunit.
PLoS One.
6:e24915
PMID: 21966384 -
Gómez-Gonzalo et al.
(2010)
An excitatory loop with astrocytes contributes to drive neurons to seizure threshold.
PLoS Biol.
8:e1000352
PMID: 20405049 -
Sun
(2009)
Experience-dependent intrinsic plasticity in interneurons of barrel cortex layer IV.
EMBO J.
102:2955
PMID: 19741102 -
Léveillé et al.
(2008)
Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors.
FASEB J.
22:4258
PMID: 18711223 -
Han et al.
(2007)
DArgic modulation of spinal neuronal excitability.
J Neurophysiol.
27:13192
PMID: 18045913 -
Lenz and Avruch
(2005)
Glutamatergic regulation of the p70S6 kinase in primary mouse neurons.
Stem Cell Reports.
280:38121
PMID: 16183639
There are no citations that match your criteria.
Customer Reviews
4.5 out of 5
2 customer ratings
Showing 1-2 of 2 reviews
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Product performed ideally over years and would buy again.
Species: RatAssay Type: In VitroCell Line/Tissue: Sprague-Dawley rats primary neuronalWe increased synaptic activity using a standard pharmacological approach (20 μM bicuculline and 100 μM 4-AP.
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Product performed ideally over years and would buy again
Species: HumanAssay Type: In VitroOur cell biology lab uses 4 Aminopyridine block Kv channels on different cell lines expressing different Kv channel from all across human body. The product works excellent and few papers have been published where it has been used. Greatly recommend.
There are no reviews that match your criteria.
