Linopirdine dihydrochloride
Catalog # 1999 | Tocris Bioscience a Bio-Techne Brand
KV7 (KCNQ) channel blocker
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Key Product Details
Description: | KV7 (KCNQ) channel blocker |
Alternative Names: | DuP 996 |
Chemical Name: | 1,3-Dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-2H-indol-2-one dihydrochloride |
Purity: | ≥99% (HPLC) |
Molecular Weight: | 464.39 |
Citations for Linopirdine dihydrochloride (12)
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Citations are publications that use Bio-Techne products. Selected citations for Linopirdine dihydrochloride include:
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Greene et al.
(2017)
XE991 and Linopirdine are state-dependent inhibitors for Kv7/KCNQ channels that favor activated single subunits.
J.Pharmacol.Exp.Ther..
362:177
PMID: 28483800 -
Lecrux et al.
(2017)
Impact of altered cholinergic tones on the neurovascular coupling response to whisker stimulation.
J Neurosci.
37:1518
PMID: 28069927 -
Carrott et al.
(2016)
Absence of Neuroplastin-65 Affects Synaptogenesis in Mouse Inner Hair Cells and Causes Profound Hearing Loss.
J Pharmacol Exp Ther.
36:222
PMID: 26740663 -
Ghezzi et al.
(2016)
Electrophysiological characterization of the M-current in rat hypoglossal motoneurons
Neuroscience.
340:62
PMID: 27984184 -
Sedivy et al.
(2015)
Role of Kv7 channels in responses of the pulmonary circulation to hypoxia.
Am J Physiol Lung Cell Mol Physiol.
308:L48
PMID: 25361569 -
Zampini et al.
(2014)
Fine Tuning of CaV1.3 Ca2+ channel properties in adult inner hair cells positioned in the most sensitive region of the Gerbil Cochlea.
PLoS One.
9:e113750
PMID: 25409445 -
Lee et al.
(2014)
Serum starvation-induced voltage-gated potassium channel Kv7.5 expression and its regulation by Sp1 in canine osteosarcoma cells.
Int J Mol Sci.
15:977
PMID: 24434641 -
Zampini et al.
(2013)
Burst activity and ultrafast activation kinetics of CaV1.3 Ca2+ channels support presynaptic activity in adult gerbil hair cell ribbon synapses.
Front Cell Neurosci.
591:3811
PMID: 23713031 -
Gigout et al.
(2012)
Distinct muscarinic acetylcholine receptor subtypes mediate pre- and postsynaptic effects in rat neocortex.
BMC Neurosci.
13:42
PMID: 22540185 -
Joshi et al.
(2009)
KCNQ modulators reveal a key role for KCNQ potassium channels in regulating the tone of rat pulmonary artery smooth muscle.
J Physiol.
329:368
PMID: 19151245 -
Anderson et al.
(2009)
KCNQ currents and their contribution to resting membrane potential and the excitability of interstitial cells of Cajal from the guinea pig bladder.
J.Urol.
182:330
PMID: 19450820 -
Luther and Birren
(2009)
p75 and TrkA signaling regulates sympathetic neuronal firing patterns via differential modulation of voltage-gated currents.
J Neurosci.
29:5411
PMID: 19403809
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Customer Reviews for Linopirdine dihydrochloride (1)
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Species: HumanAssay Type: In VitroOur lab is working with Voltage gated potassium channel for a while and I have used a few potent Kv channel blockers to measure out the % blocking showed by them. This product gave reproducible data, stable in biological lab conditions and the work was published. So overall very happy with the purchase of the compound.
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