Linopirdine dihydrochloride

Name: Linopirdine dihydrochloride
Brand: Tocris Bioscience
SKU: 1999
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1999

(1)

Citations (262)

COA / SDS

KV7 (KCNQ) channel blocker

Key Product Details

Description:	K_V7 (KCNQ) channel blocker
Alternative Names:	DuP 996
Chemical Name:	1,3-Dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-2H-indol-2-one dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	464.39

View Full Technical Details for Linopirdine dihydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for Linopirdine dihydrochloride

Linopirdine dihydrochloride is a blocker of K_V7 (KCNQ) voltage-gated potassium channels; blocks K_V7.1 + 7.3 (KCNQ2 + 3) / M-currents (IC₅₀ = 4 - 7 μM) and K_V7.1 (KCNQ1) homomeric channels (IC₅₀ = 8.9 μM). Augments hippocampal ACh release and is a cognitive enhancer following oral administration in vivo.

Compound Libraries for Linopirdine dihydrochloride

Linopirdine dihydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Linopirdine dihydrochloride

M. Wt	464.39
Formula	C₂₆H₂₁N₃O.2HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	113168-57-3
PubChem ID	14209557
InChi Key	ZEVVHCGTTNRYOY-UHFFFAOYSA-N
Smiles	Cl.Cl.O=C1N(C2=CC=CC=C2C1(CC1=CC=NC=C1)CC1=CC=NC=C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Linopirdine dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	46.44	100
	DMSO	46.44	100

Preparing Stock Solutions for Linopirdine dihydrochloride

The following data is based on the product molecular weight 464.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.15 mL	10.77 mL	21.53 mL
5 mM	0.43 mL	2.15 mL	4.31 mL
10 mM	0.22 mL	1.08 mL	2.15 mL
50 mM	0.04 mL	0.22 mL	0.43 mL

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Reconstitution Calculator

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References for Linopirdine dihydrochloride

References are publications that support the biological activity of the product.

Wang KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Science 1998 PMID: 9836639
Zaczek Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine. J.Pharmacol.Exp.Ther. 1998 PMID: 9580619
Schnee and Brown Selectivity of linopirdine (DuP 966), a neurotransmitter release enhancer, in blocking voltage-dependent and calcium-activated potassium currents in hippocampal neurons. J.Pharmacol.Exp.Ther. 1998 PMID: 9694925