Terfenadine

Tocris Bioscience, part of Bio-Techne | Catalog # 3948

H1 antagonist. Also KV11.1 (hERG) and Kir6 (KATP) channel blocker
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Key Product Details

Description

H1 antagonist. Also KV11.1 (hERG) and Kir6 (KATP) channel blocker

View all Histamine H1 Receptor Antagonists »

Product Description

Terfenadine is a histamine H1 receptor antagonist. Also blocks KV11.1 (hERG) and Kir6 (KATP) channels (IC50 values are 204 nM and 1.2 μM respectively). Inhibits the delayed rectifier K+ current (IKr) in guinea pig ventricular myocytes (IC50 = 50 nM). Activity prolongs QT and induces Torsades de pointes (TdP); cardiotoxic in vivo.

Product Specifications

Molecular Weight

471.67

Formula

C32H41NO2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

α-[4-(1,1-Dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinebutanol

CAS Number

50679-08-8

PubChem ID

5405

InChI Key

GUGOEEXESWIERI-UHFFFAOYSA-N

SMILES

OC(C3=CC=CC=C3)(C4=CC=CC=C4)C1CCN(CCCC(O)C2=CC=C(C(C)(C)C)C=C2)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 47.17 100
Ethanol 11.79 25

Preparing Stock Solutions for Terfenadine

The following data is based on the product molecular weight 471.67

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.12 mL 10.60 mL 21.20 mL
5 mM 0.42 mL 2.12 mL 4.24 mL
10 mM 0.21 mL 1.06 mL 2.12 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Terfenadine

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Terfenadine

For research use only

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