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E-4031 dihydrochloride

Tocris Bioscience a Bio-Techne Brand

Voltage-gated Potassium Channel Blockers Small Molecule
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Key Product Details

Description: KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)
Chemical Name: N-[4-[[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide dihydrochloride
Purity: ≥98% (HPLC)
Molecular Weight: 474.44

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Citations for E-4031 dihydrochloride (11)

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Customer Reviews for E-4031 dihydrochloride (2)

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  • E-4031 shortens cardiac action potential duration
    Name: Anonymous
    Species: Other
    Assay Type: In Vitro
    Cell Line/Tissue: Cardiomyocytes
    A representative action potential of a guinea pig cardiomyocyte before and after perfusion with 500 nM E-4031 for 5 min and stimulated at a frequency of 1 Hz in a whole cell patch clamp model. E-4031 significantly shortened action potential duration of guinea pig ventricular cardiomyocytes.
    E-4031 dihydrochloride Serum 1808
  • Antiarrhythmic drug E-4031 was studied to identify drug effect: Overall great product
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    As an antiarrhythmic drug E-4031 was studied to identify drug effect. Concentration dependent Kv channel blocking and control of release were studied. The compound showed blocking activity which is not dependent on concentration administered and data was reproducible. Great product stability and dissolves nicely.
    E-4031 dihydrochloride Serum 1808

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Product Documents for E-4031 dihydrochloride

Certificate of Analysis

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