E-4031 dihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 1808

KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)
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Key Product Details

Description

KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)

View all Voltage-gated Potassium Channel Blockers »

Product Description

E-4031 dihydrochloride is a selective blocker of KV11.1 (hERG) channels; inhibits the rapid delayed-rectifier K+ current (IKr). Reversibly prolongs action potential duration in guinea pig papillary muscle and isolated ventricular myocytes, without affecting Na+ or Ca2+ inward currents. Class III antiarrhythmic agent.

Product Specifications

Molecular Weight

474.44

Formula

C21H27N3O3S.2HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

N-[4-[[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide dihydrochloride

CAS Number

113559-13-0

PubChem ID

3087190

InChI Key

ZQBNWMFBOSOOLX-UHFFFAOYSA-N

SMILES

Cl.Cl.CC1=CC=CC(CCN2CCC(CC2)C(=O)C2=CC=C(NS(C)(=O)=O)C=C2)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 47.44 100
DMSO 9.49 20 with gentle warming

Preparing Stock Solutions for E-4031 dihydrochloride

The following data is based on the product molecular weight 474.44

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.11 mL 10.54 mL 21.08 mL
5 mM 0.42 mL 2.11 mL 4.22 mL
10 mM 0.21 mL 1.05 mL 2.11 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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Product Documents for E-4031 dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for E-4031 dihydrochloride

For research use only

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